knee OA. Bilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention 1: Arctium lappa root (Burdock) tea daily, for 6 weeks as well as physiotherapy (20 an-hour sessions for both knees), Acetaminophen 500mg twice a day, and Glucosamine one tablet daily for
Treatment - Other
Treatment - Drugs
Arctium lappa root (Burdock) tea daily, for 6 weeks as well as physiotherapy (20 an-hour sessions for both knees), Acetaminophen 500mg twice a day, and Glucosamine one tablet daily for 6 weeks
control: Physiotherapy (20 an-hour sessions for both knees) as well as Acetaminophen 500mg twice a day and Glucosamine one tablet daily for 6 weeks
Sponsors
Vice chancellor for Research, Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age 50-70years old; primary bilateral knee osteoarthritis based on ACR criteria; ability to consume arctium lappa tea . Exclusion criteria: grade IV osteoarthritis; secondary OA; active synovitis; knee surgery or intra-articular injection; neuromuscular diseases; diabetes; metabolic diseases; cardiovascular diseases; hepatic diseases; smoking; alcohol and MI.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain, joint stiffness and Disability. Timepoint: Before and 6 weeks after the intervention. Method of measurement: Knee injury Osteoarthritis Outcome Score (KOOS) questionnaire.;Timed up and go test. Timepoint: Before and 6 weeks after the intervention. Method of measurement: based on walking time.;Visual Analog Scale (VAS). Timepoint: Before and 6 weeks after the intervention. Method of measurement: based on line.;Inflammatory markers (IL-6). Timepoint: Before and 6 weeks after the intervention. Method of measurement: Elisa.;Hs-crp. Timepoint: Before and 6 weeks after the intervention. Method of measurement: Imonoturbidometry.;Markers of Lipidemia. Timepoint: Before and 6 weeks after the intervention. Method of measurement: Espectrophotometry(mg/dl).;Measurement of serum MDA. Timepoint: Before and 6 weeks after the intervention. Method of measurement: spectrophotometry.;Erythrocyte SOD activity. Timepoint: Before and 6 weeks after the intervention. Method of measurement: spectrophotometry.;Erythrocyte GPX activity. Timepoint: Before and 6 weeks after the intervention. Method of measurement: spectrophotometry.;Serum total antioxidant capacity. Timepoint: Before and 6 weeks after the intervention. Method of measurement: spectrophotometry. | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical activity. Timepoint: Before and 6 weeks after the intervention. Method of measurement: physical activity Questionnaire.;Macronutrients intake. Timepoint: Before and 6 weeks after the intervention. Method of measurement: 24-h recall Questionnaire.;Anthropometric index(weight and Body Mass Index). Timepoint: Before and 6 weeks after the intervention. Method of measurement: Analogue scale for weight and weight(Kg)/Square Height for body mass index. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed