Comparison of the effect of doxycycline with Omega-3 fatty acid and low-dose Aspirin on gingival crevicular fluid levels of matrix metalloproteinase-8

Comparison of the effect of adjunctive low dose doxycycline with Omega-3 fatty acid and low-dose Aspirin on gingival crevicular fluid levels of matrix metalloproteinase-8 in chronic periodontitis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013052311771N6

Enrollment

Registered

2013-06-03

Start date

2011-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention: One 20mg Capsule of Doxycycline per day. Intervention 2: One 400mg Tablet of Omega-3 fatty acid and one 80mg Tablet of Aspirin per day. Intervention 3: One Placebo Capsul

Treatment - Drugs

Placebo

Intervention: One 20mg Capsule of Doxycycline per day

One 400mg Tablet of Omega-3 fatty acid and one 80mg Tablet of Aspirin per day

One Placebo Capsule per day

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: chronic mild to moderate periodontitis. Exclusion criteria: Patients with any infectious or systemic diseases; no drug usage at all; pregnant, breast feeder patients; patients allergic to antibiotics; no scaling and root planning or periodontal surgeries in the last six months; no usage of antibiotic drugs during the last six months; Smokers, alcoholics; patients with poor oral hygiene or patients with poor compliance

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
MMP-8 concentrate in GCF. Timepoint: 0 and 6 weeks. Method of measurement: Nanogram per milliliter by means of ElLISAreader.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShirin Zahra Farhad

Islamic Azad Dental School Khorasgan Branch, (Isfahan), Iran

drsh.farhad@yahoo.com+98 31 1664 1410

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026