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Comparison of injection form of acetaminophen with morphine

Randomized clinical trial comparing intravenous Acetaminophen with Morphine on pain and peritoneal irritation signs in patients with acute surgical abdomen

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT2013052311067N2
Enrollment
120
Registered
2013-07-20
Start date
2013-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal pain and tenderness. Severe abdominal pain (generalized)(localized)(with abdominal rigidity)

Interventions

Intervention 1: In acetaminophen group, one shot of intravenous acetaminophen (trade name: Apotel) will be injected with a dose of 15 mg/kg intravenously. Intervention 2: In morphine group, one shot o
Treatment - Drugs
In acetaminophen group, one shot of intravenous acetaminophen (trade name: Apotel) will be injected with a dose of 15 mg/kg intravenously.
In morphine group, one shot of morphine (trade name: MS) will be injected with a dose of 0.1 mg/kg intravenously.

Sponsors

Vice chancellor for research, Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Patients diagnosed with acute surgical abdomen; age between 12 and 70 years old. Exclusion criteria: Patients with a history of drug addiction; patients with a history of narcotic or sedative injection in the last week.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Patient's pain. Timepoint: Before injection, 30 minutes after injection. Method of measurement: Visual analogue scale.;Patient's abdominal tenderness. Timepoint: Before injection, 30 minutes after injection. Method of measurement: Physical exam and clinical evaluation.;Patient's abdominal rebound tenderness. Timepoint: Before injection, 30 minutes after injection. Method of measurement: Physical exam and clinical evaluation.

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026