Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: Includes 20 patients who undergo intra-articular injection of 5 cc PRP in three injections at two-week intervals along with 10 high-intensity laser sessions, two se
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Individuals aged 40 to 70 years who are diagnosed with knee osteoarthritis based on history and physical examination. Duration of symptoms is more than 3 months. Diagnosis is confirmed using knee radiography (Kellgren–Lawrence grade 2-3). Patient's BMI is between 18 and 30. Patient's willingness to participate in the study
Exclusion criteria
Exclusion criteria: History of immunodeficiency and collagen disorders and uncontrolled diabetes History or presence of malignant disorders, infection or active ulcer in the knee area Recent history of severe knee injury Autoimmune and platelet disorders Treatment with anticoagulant and antiplatelet drugs within 10 days prior to injection Use of NSAIDs within 2 days prior to injection History of intramuscular injection or oral administration of systemic corticosteroids 2 weeks prior to injection History of any intra-articular knee injection within the past 6 months Hemoglobin less than 11 g/dL Platelet count less than 150,000/mL History of vasovagal shock Pregnancy or breastfeeding Genu valgum/varum greater than 20 degrees Hemarthrosis, erythema, and psoriatic lesions Clinical or paraclinical signs in favor of spinal canal stenosis, neuropathy, or active lumbar radiculopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of knee pain. Timepoint: At the beginning of the study (before the intervention) and 4 weeks and 24 weeks after the intervention. Method of measurement: Based on the visual pain index, WOMAC questionnaire, and Lequesne index.;Assessing the patient's performance in performing daily tasks. Timepoint: At the beginning of the study (before the intervention) and 4 weeks and 24 weeks after the intervention. Method of measurement: Using the WOMAC questionnaire.;Assessing morning dryness. Timepoint: At the beginning of the study (before the intervention) and 4 weeks and 24 weeks after the intervention. Method of measurement: Using the WOMAC questionnaire and Lequesne index. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient satisfaction with treatment. Timepoint: At the beginning of the study (before the intervention) and 4 weeks and 24 weeks after the intervention. Method of measurement: 5-choice questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad eyed abusaeedi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed