Comparison of the Efficacy of ultrasound guided injection of Corticosteroid, Platelet-rich Plasma(PRP), and Ozone on pain and function of patients with lateral epicondylitis

Comparison of the Efficacy of ultrasound guided injection of Corticosteroid, Platelet-rich Plasma(PRP), and Ozone on pain and function of patients with lateral epicondylitis: A multicenter randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130523013442N35

Enrollment

Registered

2023-11-19

Start date

2023-11-01

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lateral epicondylitis. Lateral epicondylitis

Interventions

Intervention 1: Intervention group: 30 patients with lateral epicondylitis who are injected with 10 ml of ozone with a concentration of 15 µg/ml under ultrasound guidance. Intervention 2: Intervention

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients with treatment-resistant tennis elbow duration of 3 months or more pain intensity of VAS 5 or more age of 20 to 50 years

Exclusion criteria

Exclusion criteria: Symptoms of an infectious disease or fever in the last few days Thyroid dysfunction or uncontrolled diabetes Rheumatic disease History of hematologic or bone malignancy Elbow joint injury Carpal tunnel syndrome and other peripheral nerve injuries including radial nerve injury Cervical radiculopathy that affects the Mayo questionnaire History of autoimmune disease Platelet disorder Treatment with antiplatelet drugs in the last 10 days Platelets below 150,000 Treatment with non-steroidal anti-inflammatory drugs within 48 hours before injection Steroid use in the past 3 weeks Hemoglobin below 10 History of vasovagal shock Pregnancy or breastfeeding Treatment of lateral epicondylitis with steroids in the last 6 months Lateral epicondylitis surgery Ozone sensitivity G6PD Taking ACE inhibitor

Design outcomes

Primary

Measure	Time frame
Pain in lateral epicondyle. Timepoint: At the beginning of the study (before the start of the intervention) and 2 months and 6 months after the intervention. Method of measurement: Visual analogue scale (VAS).;Pain pressure thresold. Timepoint: At the beginning of the study (before the start of the intervention) and 2 months and 6 months after the intervention. Method of measurement: Algometer.;Patient's performance. Timepoint: At the beginning of the study (before the start of the intervention) and 2 months and 6 months after the intervention. Method of measurement: Mayo questionnaire score.	—

Measure

Time frame

Pain in lateral epicondyle. Timepoint: At the beginning of the study (before the start of the intervention) and 2 months and 6 months after the intervention. Method of measurement: Visual analogue scale (VAS).;Pain pressure thresold. Timepoint: At the beginning of the study (before the start of the intervention) and 2 months and 6 months after the intervention. Method of measurement: Algometer.;Patient's performance. Timepoint: At the beginning of the study (before the start of the intervention) and 2 months and 6 months after the intervention. Method of measurement: Mayo questionnaire score.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahfam pourazin

Shahid Beheshti University of Medical Sciences

mahfampourazin@gmail.com+98 21 2207 4087

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026