fentanyl-induced cough. Complications of medical and surgical care,Opioids and related analgesics
Conditions
Interventions
Intervention 1: 10 mg Propofol and two minutes later, 2µg/kg fentanyl. Intervention 2: 1 ml normal saline and two minutes later, 2µg/kg fentanyl.
Treatment - Drugs
Placebo
10 mg Propofol and two minutes later, 2µg/kg fentanyl
1 ml normal saline and two minutes later, 2µg/kg fentanyl
Sponsors
Vice chancellor for research, Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Informed written consent; ASA class ?-??; Age between 18 - 50 years; Various elective surgical procedures under general anesthesia. Exclusion criteria: History of asthma, chronic cough, lung disease; Smoking or substance abuse; Cardiac disease; Any disease or surgery of trachea or larynx; Upper respiratory tract infection in the previous four weeks; Impaired kidney or liver functions; Pregnancy and lactation; Medication with angiotensin-converting enzyme inhibitors (ACE), steroids, bronchodilators, antihistamine or antitussive drugs in the previous four weeks.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough. Timepoint: Within two minutes after fentanyl injection. Method of measurement: Record in Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic blood pressure. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Noninvasive arterial blood pressure.;Diastolic blood pressure. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Noninvasive arterial blood pressure.;Mean arterial blood pressure. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Noninvasive arterial blood pressure.;Heart rate. Timepoint: First and two minutes after fentanyl injection. Method of measurement: electrocardiogram.;Oxygen saturation. Timepoint: First and two minutes after fentanyl injection. Method of measurement: Pulse oxymeter. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed