chemotherapy induced oral mucositis. Oral mucositis (ulcerative) due to antineoplastic therapy
Conditions
Interventions
Intervention 1: Intervention group: phenytoin mucoadhesive tablet Mucoadhesive tablets are prepared by direct compression method. The ingredients (10 mg sodium phenytoin and the rem
NaCMC, 25:25:50 w/w %) are weighed accurately and mixed by trituration in a mortar by pestle for 15 minutes. Then all of the ingredients are passed through sieve no. 100. Finally the mixture is compre
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: patients underwent chemotherapy process, due to various types of malignancies, without concurrent radiotherapy mucositis grade 2 or 3 (WHO criteria) prognosis for at least 6 months signing the consent form
Exclusion criteria
Exclusion criteria: Patients with mucositis of grade 1 or 4 sign of causing side effects (such as sensitivity to phenytoin) lack of patient cooperation or trend to complete the treatment process systemic diseases with oral mucositis (such as connective tissue diseases and Sjogren syndrome)or interfering with healing process of tissues (such as diabetes) smoking and alcohol consumption
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Grade of oral mucositis and pain. Timepoint: before intervention, 1 and 2 weeks after intervention. Method of measurement: WHO grading and Visual analogue scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFahimeh Rezazadeh
Shiraz University of Medical Sciences
Outcome results
None listed