The effect of normal saline with or without sodium bicarbonate in preventing contrast induced nephropathy in coronary angiography

The effect of hydration with normal saline with or without sodium bicarbonate in preventing contrast induced nephropathy in coronary angiography

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201305205311N2

Enrollment

350

Registered

2013-05-26

Start date

2011-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephropathy. Nephropathy induced by other drugs, medicaments and biological substances

Interventions

Intervention 1: In normal saline group, normal saline will be infused 6 hours before and 6 hours after injection of contrast media. Intervention 2: In normal saline and bicarbonate group, normal salin

Treatment - Drugs

In normal saline group, normal saline will be infused 6 hours before and 6 hours after injection of contrast media.

In normal saline and bicarbonate group, normal saline and sodium bicarbonate will be infused 6 hours before and 6 hours after injection of contrast media.

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients undergo elective coronary angiography. Exclusion criteria: pre-existing end-stage renal disease requiring dialysis; cardiogenic shock; uncontrolled hypertension; recent exposure to radiographic media; serum creatinine level above 4 mg/dl

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Contrast induced nephropathy. Timepoint: 6 hours before and 48 hours after intervention. Method of measurement: measuring serum creatinine.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Bahram Sohrabi

Tabriz University of Medical Sciences

sohrabib@tbzmed.ac.ir+98 41 1336 3846

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026