The effect of metformin and diet on metabolic syndrome treatment

Comparison of the effect of low glycemic index diet and metformin drug on metabolic syndrome components in adults with metabolic syndrome

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013052013399N1

Enrollment

Registered

2014-03-02

Start date

2013-08-24

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

metabolic syndrome. Endocrine, nutritional and metabolic diseases

Interventions

Intervention 1: For the diet group the percentage of required energy will be calculated with Harris-Benedict formula.The percentage of macronutrients are the same for all participants and will be 50%

Lifestyle

Treatment - Drugs

For the diet group the percentage of required energy will be calculated with Harris-Benedict formula.The percentage of macronutrients are the same for all participants and will be 50% carbohydrate,30%

The dose of administration for the metformin group will be 500mg (1 oral tab daily) for 8 weeks.

Eligibility

Sex/Gender

All

Age

25 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Having 3 characteristics related to metabolic syndrome according to ATPIII ( Adult Treatment Panel): waist Circumference =40 (men) or =35 inches (women), Blood Pressure =135 (systole) or =85 (diastole) mmHg, Fasting Blood Sugar =100mg/dl, Triglycerides =150mg/dl, and High-Density Lipoproteins <40 (men) or <50 mg/dl (women). Of course the waist circumference size for Asian men is =90 cm and for Asian women is =58 cm. Not taking any drug that might affect blood pressure and glucose , insulin or lipid metabolism . Not having diabetes, liver or kidney diseases . Exclusion criteria: Patients will be excluded if they get gastrointestinal disorders or lose their interest to continue the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Weight. Timepoint: before the intervention, 8weeks after the intervention. Method of measurement: seca weighing machine.;Blood pressure. Timepoint: before intervention ,8weeks after intervention. Method of measurement: mmgh-piezometer.;Lipid profile (TG,HDL,LDL,total Chol). Timepoint: before intervention,8weeks after intervention. Method of measurement: biosystem autoanalyzer bt1500.;Fasting blood sugar. Timepoint: before the intervention, 8 weeks after the intervention. Method of measurement: biosystem autoanalyzer bt1500.;Waist circumference. Timepoint: before intervention ,8weeks after intervention. Method of measurement: centimeter-tape measure.	—

Measure

Time frame

Weight. Timepoint: before the intervention, 8weeks after the intervention. Method of measurement: seca weighing machine.;Blood pressure. Timepoint: before intervention ,8weeks after intervention. Method of measurement: mmgh-piezometer.;Lipid profile (TG,HDL,LDL,total Chol). Timepoint: before intervention,8weeks after intervention. Method of measurement: biosystem autoanalyzer bt1500.;Fasting blood sugar. Timepoint: before the intervention, 8 weeks after the intervention. Method of measurement: biosystem autoanalyzer bt1500.;Waist circumference. Timepoint: before intervention ,8weeks after intervention. Method of measurement: centimeter-tape measure.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Zohre Mazlom

Nutrition Faculty

zohremazlom@yahoo.com+98 71 1725 1001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026