Osteoarthritis of knee. Bilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: Intervention group is injected calcitonin (50 IU/ml intramuscularly) once a week for 4 consecutive weeks, and in case of pain, AcetaGel (500mg) and piroxicam (0.5%
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
35 Years to 75 Years
Inclusion criteria
Inclusion criteria: Age between 35-75 years knee pain during past 6 months At least two clinical symptoms of joint inflammation based on ACR criteria for osteoarthritis
Exclusion criteria
Exclusion criteria: unwillingness to participate in the study History of cardiovascular disease History of renal disease History of hepatic disease History of gastrointestinal disease History of coagulopathy History of intra-articular injection into the affected knee within 3 months before Currently using DMOADS agents (hydroxychloroquine, sulfasalazine, methotrexate, cyclosporine, azathioprine) Pre-existing allergies to calcitonin Previous knee arthroplasty Recent history of substance abuse Those who cannot report the result reliably due to cognitive impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: At the beginning of the study (before the intervention) and two months after. Method of measurement: VAS.;WOMAC Index. Timepoint: At the beginning of the study (before the intervention) and two months after. Method of measurement: The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrdad Taheri
Shahid Beheshti University of Medical Sciences
Outcome results
None listed