obsessive-compulsive disorder. Obsessive-compulsive disorder
Conditions
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients with obsessive-compulsive disorder who have been treated with high doses of SSRI for at least 8 weeks but whose Y-BOCS index is higher than cut-off 15.People aged 18 to 60 yearsObtain patient informed consent People aged 18 to 60 years Obtain patient informed consent
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding Using serotonergic drugs other than SSRIs Use of NMDA receptor antagonists other than memantine and dextromethorphan Major Depressive Disorder (Based on DSM-IV-TR Criteria) Psychotic and bipolar disorders (based on DSM-5 criteria) Other anxiety disorders (such as panic disorder, post-traumatic stress disorder (PTSD), general anxiety disorder (GAD) Abuse or dependence on drugs or alcohol Liver dysfunction (LFT> 3ULN) Kidney dysfunction (GFR <60 ml / kg / min) Thyroid Disorders (Based on Thyroid Function Test) History of seizures Cognitive-behavioral therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changing of the latency and amplitude of brainwave components in the ERP study. Timepoint: Before intervention and 1 month, 2 months and 3 months after intervention. Method of measurement: Yale–Brown Obsessive Compulsive Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in quantitative electroencephalography (QEEG). Timepoint: Before intervention and 3 months after intervention. Method of measurement: Quantitative Electroencephalogram. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSadjadi Alireza
Mashhad University of Medical Sciences
Outcome results
None listed