Post-treatment pain after root canal therapy. Diseases of pulp and periapical tissues
Conditions
Interventions
Intervention 1: saffron stigma extract with dose of 10 mg in each pink opaque capsule in 0, 6, 12, 24, 48 h after treatment. Intervention 2: 400 mg ibuprofen in each pink opaque
capsule in 0, 6, 12,
Treatment - Drugs
saffron stigma extract with dose of 10 mg in each pink opaque capsule in 0, 6, 12, 24, 48 h after treatment
400 mg ibuprofen in each pink opaque
capsule in 0, 6, 12, 24, 48 h after treatment
saffron petal extract with dose of 10 mg in each pink opaque capsule in 0, 6, 12, 24, 48 h after treatment
Sponsors
Zahedan University of Medical Sciences, Vice-chancellor for research
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-vital teeth with one root canal; 2- moderate to severe pain; 3-patients over 18 years old; 4- patients with at least high school education. Exclusion criteria: 1- teeth with periapical lesions based on radiographic; 2- patients with history of allergy to saffron; 3- patients with history of allergy to NSAID; 4- diabetes mellitus, cardiovascular disorders, kidney and liver diseases, blood and hormonal disorders and electrolyte imbalance; 5- use of analgesics or opioids during 4 hours before treatment; 6- women in pregnancy or breast feeding period.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: 0 - 6 - 12 - 24 and 48 hours after root canal treatment. Method of measurement: Visual Analog Scale (VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Lack of pain intensity. Timepoint: 0-6-12-24-48. Method of measurement: Visual Analog Scale(VAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMojtaba Bazrafshan
Zahedan University of Medical Sciences
Outcome results
None listed