Condition 1: acute sore throat. Condition 2: hoarseness. Acute pharyngitis, unspecified Dysphonia
Conditions
Interventions
Intervention 1: Group K, who gargled 40mg ketamine in 30 ml normal saline for 30 s and received 2mg/kg intravenous saline, 5 min before induction anesthesia. Intervention 2: Group D, who gargled 30ml
Prevention
Group K, who gargled 40mg ketamine in 30 ml normal saline for 30 s and received 2mg/kg intravenous saline, 5 min before induction anesthesia.
Group D, who gargled 30ml normal saline for 30 s and received 0.2mg/kg intravenous dexamethasone, 5min before induction anesthesia.
Group KD, who gargled 40 mg ketamine in 30 ml normal saline and received 0.2mg/kg intravenous dexamethasone, 5min before induction anesthesia.
Group P who received a placebo of normal saline (gargled 30 ml normal saline for 30 s and received 0.2mg/kg intravenous normal saline, 5min before induction of anesthesia).
Sponsors
Anesthesiology and Critical Care Research Center,Isfahan University of Medical Sciences, Isfahan, Ir
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients without a history of preoperative sore throat and asthma;Patients without recent NSAID medication; mouth opening of >3.5cm;a Cormack score of lower than 4; patients with duration of surgery between 60-300 min ;known allergies to study drugs; known difficulty with tracheal intubation. Exclusion criteria were: Those who required more than one attempt for tracheal intubation; Patients with the requirement of mechanical lung ventilation after surgery in the intensive care unit.
Exclusion criteria
Exclusion criteria:
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Recovery time(min). Timepoint: times from discontinuation of anesthesia until the time to achieve a modified Aldrete score of 9. Method of measurement: aldrete score.;The duration of tracheal intubation. Timepoint: the duration of tracheal intubation. Method of measurement: watching.;Sedation. Timepoint: during interviewed the patients to investigate the POST(post operative sore throat) (0,2,4,8,16,24h after tracheal extubation). Method of measurement: using the four-point Observer’s Assessment of Alertness/ Sedation (OAA/S) scale (where 0 = awake/alert and 3 = deep sleep). | — |
Primary
| Measure | Time frame |
|---|---|
| Sore throat. Timepoint: On arrival in the post-anesthesia care unit (0 h), and at 2, 4, 8,16and 24 h thereafter,. Method of measurement: 0, no sore throat; 1, mild sore throat (complains of sore throat only on asking); 2, moderate sore throat (complains of sore throat on his/her own); and 3, severe sore throat (change of voice or hoarseness, associated with throat pain).;Hoarseness. Timepoint: On arrival in the post-anesthesia care unit (0 h), and at 2, 4, 8,16and 24 h thereafter,. Method of measurement: watching-0, No hoarseness; 1, Hoarseness at the time of interview, but noted only by patient; 2, Hoarseness that is readily apparent, but mild; 3, Hoarseness that is readily apparent and severe. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Azim Honarmand
Isfahan University of Medical Sciences, Isfahan, Iran
Outcome results
None listed