prediabetes. Impaired glucose tolerance prediabetes
Conditions
Interventions
Intervention 1: In first intrvention group,prediabetic individuals,aged 30-65 years, will recieve a daily allotment of 20 gr ground flaxseed for 12 week.they will be instructed to incorporate the supl
Treatment - Other
In first intrvention group,prediabetic individuals,aged 30-65 years, will recieve a daily allotment of 20 gr ground flaxseed for 12 week.they will be instructed to incorporate the suplement in their
In second intrvention group, prediabetic individuals,aged 30-65 years, will recieve a daily allotment of 40 gr ground flaxseed for 12 week.they will be instructed to incorporate the suplement in the
In control group,prediabetic individuals,aged 30-65 years, will recieve no intervention.The subjects are told not to change diet and activity level.
Sponsors
Shahid Sadoughi University of Medical Science,International branch
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:willing to follow study protocol, scheduling, and testing location ;men and women 30 to 65 years; Body mass index (BMI) of 25 - 34.9 Kg / m2 ;prediabetic patients with fasting blood sugar of 100 -125mg/ dl or a two-hour blood sugar between 140 to 199 mg/ dl;not using Insulin ang other glucose lowering medicatins;non smoking status; not using herbal , antioxidant supplementation and omega-3 until 3 months before intervention;without any history of gastrointestinal and kindney disorder;without any acute thyroid, kidney, liver, CVD diseases Exclusion criteria:unwillingness to follow study protocol, scheduling, and testing location;diagnosis of type 2 diabetes;smoking at least 2 tmes a week;regular history of flaxseed or flaxseed oil supplement or any omega-3 supplement intake ;taking glucose lowering drugs or insulin or estrogen or progesterone drugs ;pregnancy and lactation
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum concentration of MDA. Timepoint: before and 3 months after intervention. Method of measurement: with spectrophotometer.;Serum total antioxidant capacity. Timepoint: before and 3 months after intervention. Method of measurement: cation decolorization assey ABTS.;Insulin resistance. Timepoint: before and 3 months after intervention. Method of measurement: HOMA-IR index.;Beta-cell function. Timepoint: before and 3 months after intervention. Method of measurement: ELISA kit.;Insulin sensitivity. Timepoint: before and 3 months after intervention. Method of measurement: QUICKI index. | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: before and after intervention. Method of measurement: scale with accuracy 100 gr.;Height. Timepoint: before and after intervention. Method of measurement: tape meter instaled on the wall.;BMI(Body Mass Index). Timepoint: before and after intervention. Method of measurement: Calculation:Weight (kg) / squared height (m).;Total energy intake. Timepoint: before and after intervention. Method of measurement: 24 hour recall.;Charbohydate intake. Timepoint: before and after intervention. Method of measurement: 24 hour recall.;Protein intake. Timepoint: before and after intervention. Method of measurement: 24 hour recall.;Fat intake. Timepoint: before and after intervention. Method of measurement: 24 hour recall.;Fiber intake. Timepoint: before and after intervention. Method of measurement: 24 hour recall.;Saturated fatty acid intake. Timepoint: before and after intervention. Method of measurement: 24 hour recall.;Mono unsaturated fatty acid intake(MUFA). Timepoint: before and after intervention. Method of measurement: 24 hour recall.;Poly unsaturated fatty acid intake(PUFA). Timepoint: before and after intervention. Method of measurement: 24 hour recall. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfrooz Javidi
Shahid Sadoughi University of Medical Science-Intrnational branch
Outcome results
None listed