toxic effect of creatine supplementation

Effect of creatine loading plus one week maximal resistance training on urinary formaldehyde and some serum enzymes in male wrestlers

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201305124663N15

Enrollment

Registered

2014-05-04

Start date

2012-11-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug or medicament, unspecified. Drug or medicament, unspecified

Interventions

The subjects in Creatine without training group will intake 300 mg/kg/day creatine monohydrate for 7 days.

Intervention 1: The subjects in Creatine plus training group will intake 300 mg/kg/day creatine monohydrate for 7 days. Intervention 2: The subjects in placebo group will intake 300 mg/kg/day maltodex

Treatment - Drugs

Placebo

The subjects in Creatine plus training group will intake 300 mg/kg/day creatine monohydrate for 7 days.

The subjects in placebo group will intake 300 mg/kg/day maltodexterine for 7 days.

Eligibility

Sex/Gender

Male

Age

18 Years to 26 Years

Inclusion criteria

Inclusion criteria: Inclusion:male; 18-26 years old; healthy; wrestling athletes;BMI<12; at least 3 years of professional wrestling experience; without any creatine consumption( during 3 months prior to the stud) Exclusion: Diseases; Injuries; Uncontrolled intake of creatine supplements during the period

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Urinary formaldehyde. Timepoint: 24 hour before and after the Cr loading phase. Method of measurement: Gas chromatography–mass spectrometry (GC-MS).;Ceartine kinase (CK). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).;Lactate Dehydrogenase(LDH). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).;Alanine aminotransferase (ALT). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).;Aspartate aminotransferase (AST). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).	—

Measure

Time frame

Urinary formaldehyde. Timepoint: 24 hour before and after the Cr loading phase. Method of measurement: Gas chromatography–mass spectrometry (GC-MS).;Ceartine kinase (CK). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).;Lactate Dehydrogenase(LDH). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).;Alanine aminotransferase (ALT). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).;Aspartate aminotransferase (AST). Timepoint: 24 hour before and after supplementation protocol. Method of measurement: photometric methods with commercial kits (Bionik kit).

—

Secondary

Measure	Time frame
Blood Pressure. Timepoint: 30 minutes before and after firs and last trainig session. Method of measurement: Aneroid blood pressure measurement.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Afshar Jafari

University of Tabriz

ajafari@tabrizu.ac.ir naseri_azadeh@yahoo.com+98 41 1339 3251

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026