Tubal pregnancy. Fallopian pregnancy
Conditions
Interventions
Intervention 1: After diagnosis of tubal EP and determining basic ß–hCG titration level and checking kidney, liver function tests and Complete Blood Count (CBC) Methotrexate with a brand name EBETREX
Treatment - Drugs
After diagnosis of tubal EP and determining basic ß–hCG titration level and checking kidney, liver function tests and Complete Blood Count (CBC) Methotrexate with a brand name EBETREX manufactured by
Sponsors
Vice Chancellor for Research, Guilan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
15 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1- Andexal mass with a size of 4 cm at maximum ; 2- ß–hCG titration level less than15000 mIU/mL; 3- Stable hemodynamic status -Blood Pressure > 90/60 mmHg and nonexistence of tachycardia ( Pulse Rate less than 100/min); 4-No fetal heart activity in gestational sac; 5- Consent for Methotrexate therapy and follow-up; 6- Normal laboratory tests(Platelet count more than 120000/µL , Serum Creatinin less than 1.2mg/dL or Aspartate aminotransferase less than double of normal level). Exclusion criteria: This study has not exclusion criteria .
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment response in terms of basic ß-hCG titration level by ELIZA technique. Timepoint: After first week of treatment and 6 weeks follow-up period. Method of measurement: Determining ß-hCG titration level before treatment by ELIZA technique.;Therapeutic response to methotrexate. Timepoint: Day 4 and day 7, and its repetition weekly until 6 weeks. Method of measurement: Visit the patient and determining serum ß–hCG titration level by ELIZA technique.;Treatment response in terms of longest ectopic mass diameter on Transvaginal Sonography. Timepoint: After first week of treatment and 6 weeks follow-up period. Method of measurement: Determining the longest ectopic mass diameter in terms of Ultrasound report before treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Follow-up days. Timepoint: After treatment and since first week of follow-up. Method of measurement: Duration of Treatment and follow-up until ß–hCG titration level declined to less than 10 mIU/mL in terms of day by ELIZA technique.;Methotrexate side effects(Abdominal pain,Gastrointestinal symptoms,Alopecia ,Mucositis,Leukocyte count<4000,Platelet count<120000, Aspartate aminotransferase more than double level of normal). Timepoint: After treatment and on first week of follow up. Method of measurement: History, checking liver function tests and Complete Blood Count (CBC). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAidin Raoofinia
Guilan University of Medical Sciences
Outcome results
None listed