Evaluation of Sodium Bicarbonate Effect on Contrast-induced Acute Kidney Injury Following Diagnostic Coronary Angiography

A Clinical Trial of Comparison between Sodium Bicarbonate and Sodium Chloride Effects for Prevention of Contrast-Induced Acute Kidney Injury Following Diagnostic Coronary Angiography

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013050813115N1

Enrollment

158

Registered

2013-05-29

Start date

2013-06-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Ischemic heart diseases. Condition 2: Ischemic heart diseases. Condition 3: Ischemic heart diseases. Condition 4: Ischemic heart diseases. Condition 5: Ischemic heart diseases. Angina pectoris Acute myocardial Infarction Other acute ischemic heart diseases Chronic ischemic heart disease Subsequent myocardial infarction

Interventions

Intervention 1: Treatment group: sodium bicarbonate (154 mEq/l in serum DW5%) as 3 mg/kg/h during 1-hour prior to coronary angiography and as 1 mg/kg/h during 6-hour following coronary angiography. In

Prevention

Treatment group: sodium bicarbonate (154 mEq/l in serum DW5%) as 3 mg/kg/h during 1-hour prior to coronary angiography and as 1 mg/kg/h during 6-hour following coronary angiography

Control group: sodium chloride 0.9% as 1 mg/kg/h through 12 hours before and after coronary angiography

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The major inclusion criteria include creatinin level greater than 1.5 mg/dl in men and greater than 1.4 mg/dl in women; creatinin clearance less than 60 ml/min/1.73 m2; older than 18-year-old; and history of diabetes mellitus for more than one year. The exclusion criteria include cardiogenic shock; heart failure; acute coronary syndrome recently undergone angiography or angioplasty; recent dialysis; single kidney; and any infusion of contrast media such as radiologic interventions.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Creatinine. Timepoint: prior angiography and at 48 hours after angiography. Method of measurement: Serum level, mg/dl.	—

Secondary

Measure	Time frame
Creatinin change. Timepoint: Prior angiography and 48 hours after angiography. Method of measurement: serum level, mg/dl.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactYousef Rezaei

Kermanshah University of Medical Sciences

yousefrezaei1986@gmail.com+98 912 623 1864

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026