pre-diabetes (IFG or IGT). Impaired glucose toleranceR73.0Diabetes: chemical latent Impaired glucose tolerance Prediabetes
Conditions
Interventions
Intervention 1: In Case Group/Vitamin D Group :Vitamin D will be administered as PO (15 Vitamin D pearls). In the first 3 months, the subjects will take one pearl (50,000 IU) every week. Then three
Treatment - Drugs
In Case Group/Vitamin D Group :Vitamin D will be administered as PO (15 Vitamin D pearls). In the first 3 months, the subjects will take one pearl (50,000 IU) every week. Then three pearls will be
In the Control Group, placebo pearls (using paraffin and prepared by Zahravi Pharmaceutical Company) with the same size, shape, and color as the original ones will be administered as PO (15 Vitamin
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: adult patients who are over 18 years old; pre-diabetes (IFG or IGT) and vitamin-D deficiency; obtaine informed consent. Exclusion criteria: overt Diabetes Mellitus; condition which interfere with glucose metabolism (malignancy, CRF, , inflammatory disease...); diseases like thyroid disease or mal-absorption; take medication that interfere with glucose metabolism (Steroids, HRT,Diuretics).
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diabetes(75gr-OGTT):Assessment of fasting plasma glucose after at least 8-hours fasting then 2 hours after administration of 75 gram glucose, Insulin resistance evaluated by calculating HOMA-IR. Timepoint: Befor intervention, 3 and 6 months after intervention. Method of measurement: Fasting plasma sample for evaluation of FPG and Serum insulin,Oral glucose tolerance test(OGTT) with 75gr glucose. | — |
Secondary
| Measure | Time frame |
|---|---|
| Height, weight, BMI, weist circmfrence. Timepoint: Every 3 month. Method of measurement: height (cm), weight (kg), BMI (kg/squired meters), weist circmfrence(cm). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahtab Niroomand
Shahid Beheshti University of Medical Sciences
Outcome results
None listed