Effects of Clonidine and Nifedipine on Hemodynamic Changes due to Laparoscopic Cholecystectomy

Comparison the Effects of Oral Clonidine versus Oral Nifedipine on Hemodynamic Changes During Laparoscopic Cholecystectomy under General Anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201305015471N1

Enrollment

Registered

2013-08-03

Start date

2012-06-11

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholecystitis. Disorders of gallbladder and biliary tract in diseases classified elsewhere

Interventions

Intervention 1: Patients in the first group, received 150µg oral clonidine (trademark Catapres, made in Tolid Darou Pharma Company in Iran) 30 minutes before induction of anesthesia. Intervention 2: P

Prevention

Placebo

Patients in the first group, received 150µg oral clonidine (trademark Catapres, made in Tolid Darou Pharma Company in Iran) 30 minutes before induction of anesthesia

Patients in the second group, received 10mg oral nifedipine (trademark Adalat, made in Tolid Darou Pharma Company in Iran) 30 minutes before induction of anesthesia

Patients in the third group, received tablet of vitamin C (placebo) 30 minutes before induction of anesthesia

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1- Laparoscopic cholecystectomy 2- Age range between 20-60 years 3- ASA class I-II Exclusion criteria 1- Positive history of systemic hypertension, congestive heart failure and aortic stenosis 2- Positive history of antihypertensive, narcotic and sedative drugs consumption 3- Patient refusal 4- Operation time more than 2 hours

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Blood pressure and heart rate after clonidine and nifedipine administration. Timepoint: Before induction of anesthesia, before surgical incision, before carbon dioxide insufflation and then every 5 minutes until the end of first hour of recovery period. Method of measurement: Noninvasive cardiovascular monitoring.	—

Secondary

Measure	Time frame
Postoperative Pain. Timepoint: One hour after operation in recovery period and then for 24 hours in ward. Method of measurement: By Visual Analog Scale was determined and recorded in the questionnaire.;Shivering. Timepoint: One hour after operation in recovery period. Method of measurement: By observational method was determined and recorded in the questionnaire.;Nausea and vomiting. Timepoint: One hour after operation in recovery period. Method of measurement: By observational method was determined and recorded in the questionnaire.	—

Measure

Time frame

Postoperative Pain. Timepoint: One hour after operation in recovery period and then for 24 hours in ward. Method of measurement: By Visual Analog Scale was determined and recorded in the questionnaire.;Shivering. Timepoint: One hour after operation in recovery period. Method of measurement: By observational method was determined and recorded in the questionnaire.;Nausea and vomiting. Timepoint: One hour after operation in recovery period. Method of measurement: By observational method was determined and recorded in the questionnaire.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMeisam Rezaei M.D.

Qazvin University of Medical Sciences

rezaei.meisam@yahoo.co.uk+98 28 1332 0107

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026