The effect of Oleoyl ethanolamide (OEA) supplementation in patients with acute ischemic brain stroke

The effect of Oleoyl ethanolamide (OEA) supplementation on blood hematological parameters, lipid profile, biomarkers of oxidative stress and inflammatory parameters in the blood of patients with acute ischemic brain stroke

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130501013194N4

Enrollment

Registered

2019-12-28

Start date

2020-01-20

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute ischemic brain stroke. Cerebral infarction, unspecified

Interventions

Intervention 1: Intervention group: They take one oleoyl ethanolamide supplement (200 mg) daily for two months. Supplements are made by Karen. Intervention 2: Control group: They receive a placebo cap

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Willingness to cooperate Acute ischemic brain stroke (preferably under one month)

Exclusion criteria

Exclusion criteria: taking immunosuppressive drugs History of rheumatic and collagenvascular diseases History of recent infections (within 2 to 3 months) Swallowing disorders that are unable to take medication Sensitivity to compounds No regular use of supplements Not willing to cooperate Diabetes kidney disease

Design outcomes

Primary

Measure	Time frame
Red blood cells. Timepoint: Before and after intervention. Method of measurement: Laboratory.;White blood cells. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Platelets. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Alanine aminotransferase. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Aspartate aminotransferase. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Cholesterol. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Triglyceride. Timepoint: Before and after intervention. Method of measurement: Laboratory.;High density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Low density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Urea. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Creatinine. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Lipid peroxidation. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Protein oxidation. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Total antioxidant capacity. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Catalase activity. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Tumor necrosis factor alpha. Timepoint: Before and after intervention. Method of measurement: ELISA.;Interleukin 17. Timepoint: Before and after intervention. Method of measurement: ELISA.;Reactive Protein C. Timepoint: Before and after intervention. Method of measurement: Turbidometry.	—

Measure

Time frame

Red blood cells. Timepoint: Before and after intervention. Method of measurement: Laboratory.;White blood cells. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Platelets. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Alanine aminotransferase. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Aspartate aminotransferase. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Cholesterol. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Triglyceride. Timepoint: Before and after intervention. Method of measurement: Laboratory.;High density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Low density lipoprotein. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Urea. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Creatinine. Timepoint: Before and after intervention. Method of measurement: Laboratory.;Lipid peroxidation. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Protein oxidation. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Total antioxidant capacity. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Catalase activity. Timepoint: Before and after intervention. Method of measurement: Using spectrophotometer.;Tumor necrosis factor alpha. Timepoint: Before and after intervention. Method of measurement: ELISA.;Interleukin 17. Timepoint: Before and after intervention. Method of measurement: ELISA.;Reactive Protein C. Timepoint: Before and after intervention. Method of measurement: Turbidometry.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAkram Ranjbar

Hamedan University of Medical Sciences

a.ranjbar@umsha.ac.ir+98 81 3827 4191

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026