Effect of human embryo defragmentation on pregnancy rate in intracytoplasmic sperm injection cycles

Effect of human embryo fragment removal, debris removal in perivitelline space and detachment of cumulus cells on pregnancy rate in intracytoplasmic sperm injection cycles

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013043010415N3

Enrollment

Registered

2013-05-13

Start date

2013-05-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility. Azoospermia, Oligospermia

Interventions

Intervention 1: Intervention group: laser assisted zona hatching. Intervention 2: Intervention group: removal of fragments around the blastomeres. Intervention 3: Intervention group: removal of debris

Intervention group: laser assisted zona hatching

Intervention group: removal of fragments around the blastomeres

Intervention group: removal of debris in PVS

Intervention group: detachment of attached cumulus cells to embryo

Control group: laser assisted zona hatching

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: Embryos categorized in grade B and C (according to Hill criteria); ICSI cycles. Exclusion criteria: Women with advanced age; conventional IVF cycles; non-ejaculated spermatozoa; the patient who has one embryo.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: ultrasonography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammad Ali Khalili

Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences

khalili59@hotmail.com+98 35 1824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026