Cerebral aneurism ?. Subarachnoid haemorrhage from intracranial artery, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Magnesium sulphate 50%, 20 mg/kg diluted in 100 ml of saline normal, manufactured by Pasteur Institute of Iran, during 15 minutes before infusion of anesthesia and
Treatment - Drugs
Intervention group: Magnesium sulphate 50%, 20 mg/kg diluted in 100 ml of saline normal, manufactured by Pasteur Institute of Iran, during 15 minutes before infusion of anesthesia and 10 mg/kg/hour ti
Control group: Normal Saline 0.9%, Fluid therapy During surgery according to standard procedures (Rule 4-2-1) and compensation bleeding occurs with three times of Normal Saline 0.9%
Sponsors
Vice Chancellor for Research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 61 Years
Inclusion criteria
Inclusion criteria: The major inclusion criteria?:? candidate for brain aneurysm surgery after 3 days of aneurysm bleeding;? American Society of Anesthesiologists (ASA) class I and II.? The major exclusion criteria:? pathology of cardiovascular system; heart failure [Ejection fraction (EF) less than ??40%]. Previous history of hypertension; Liver or kidney diseases (impaired Liver function ?test (FT) and Glomerular filtration rate (GFR) less than 50 ml/min); Motor, ?neurological, and muscle disorders, coagulopathy [Prothrombin time (PT) more than ??16, International Normalized Ratio (INR) more than 1.5; Partial thromboplastin ?time (PTT) more than 35]; Hypomagnesaemia, More than 60 years of age;? History of allergy to any of the used medications in the experiment,? ? Overweight [Body mass index (BMI) more than 30]; Previous use of calcium channel ?blockers; Atrioventricular block.?
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vasospasm. Timepoint: After intervention, daily. Method of measurement: Angiography and transcranial Doppler.;Mean arterial pressure. Timepoint: Before infusion, 5 minutes after infusion, every 15 minutes after infusion. Method of measurement: Arterial Line during the surgery.;Heart rate. Timepoint: Before infusion, 5 minutes after infusion, every 15 minutes after infusion. Method of measurement: Heart monitoring during the surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Bleeding rate. Timepoint: End of surgery. Method of measurement: Based on CC of gases and suction contents.;The amount of anesthetic drugs used (propofol 2 mg/kg, fentanyl 2 mcg/kg, atracurium 0.5 mg/kg lidocaine 1.5 mg/kg). Timepoint: End of surgery. Method of measurement: Based on patient weight (kg) and Duration of Surgery. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHouman Bahar Vahdat
Ghaem Hospital
Outcome results
None listed