Post intubation hemodynamic effects of intravenous lidocaine in patients with severe brain trauma

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013042813150N1

Enrollment

100

Registered

2013-05-08

Start date

2013-04-30

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with severe head trauma. Intracranial injury

Interventions

Intervention 1: In the control group patients before intubation only common protocols (conventional pharmacological protocol for patients with head trauma (succinylcholine 1.5 mg / kg + rapid intraven

Treatment - Drugs

In the control group patients before intubation only common protocols (conventional pharmacological protocol for patients with head trauma (succinylcholine 1.5 mg / kg + rapid intravenous fentanyl 2 m

Intervention group patients before intubation in addition to standard protocols (conventional pharmacological protocol for patients with head trauma (succinylcholine 1.5 mg / kg + rapid intravenous fe

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: all patients aged 65-18 years with traumatic brain injury with GCS <9; patients who have been intubated prior to admission to the emergency room; before referring patients to the emergency room, and inotropic drugs have not received isotonic fluids. Exclusion criteria: patients aged 18 years and above 65 year; patients with heart failure; in patients with shock, hypovolemia, sepsis and cardiogenic reason; patients with a previous history of heart disease and hypertension; start inotropic drugs before intubation and evidence of cardiac arrhythmia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart Rate. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.;Systolic Arterial pressure. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.;Diastolic arterial pressure. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.;Mean arterial pressure. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.	—

Measure

Time frame

Heart Rate. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.;Systolic Arterial pressure. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.;Diastolic arterial pressure. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.;Mean arterial pressure. Timepoint: Once before and once after intubation. Method of measurement: by an automatic blood pressure cuff.

—

Secondary

Measure	Time frame
The rate of use of isotonic fluids. Timepoint: After intubation. Method of measurement: Chart of Fluids.;The rate of use of inotropic agents. Timepoint: After intubation. Method of measurement: Chart of drugs.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr mohammad Ali Najjari Asl

Tabriz University of Medical Sciences

ali_njr@yahoo.com+98 41 1658 6302

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026