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Effect of glargine insulin on hyperglycemic control in type II diabetic patients

A clinical trial to compare the effectiveness of glargine insulin and regular insulin in hyperglycemic control among type II diabetic patients undergoing on-pump coronary artery bypass graft before, during, and after the operation

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130428013159N12
Enrollment
80
Registered
2020-06-16
Start date
2020-08-22
Completion date
Unknown
Last updated
2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Type II diabetic. Condition 2: Cardiovascular disease. Type 2 diabetes mellitus Chronic ischaemic heart disease

Interventions

Intervention 1: Intervention group: The intervention group will receive 0.2 units/kg glargine insulin 2 hours before the surgery. Based on the Van den Berghe national protocol, regular insulin injecti
accordingly, each patient will receive 4 units of regular subcutaneous insulin injection for every 40. Intervention 2: Control group: The control group will receive 0.2 units/kg dextrose 5% 2 hours be

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age of 35-65 years Sustaining ASA II Blood sugar of 150-350 mg/dl Lack of a simultaneous emergency surgery or heart valve surgery

Exclusion criteria

Exclusion criteria: Having underlying diseases (e.g., pulmonary, liver, kidney, thyroid, and digestive diseases) Having history of open-heart surgery Fever Trauma Carotid artery involvement Sensitivity to insulin glargine

Design outcomes

Primary

MeasureTime frame
Blood glucose. Timepoint: Before the surgery, every 2 hours intraoperatively, and every 4-24 hours after the surgery. Method of measurement: Glucose meter.

Secondary

MeasureTime frame
Long hospital days in ICU. Timepoint: After intervention. Method of measurement: The questionnaire.;Type of antibiotic used. Timepoint: After intervention. Method of measurement: The questionnaire.;Wound dehiscence. Timepoint: After intervention. Method of measurement: The questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShima Sheybani

Mashhad University of Medical Sciences

Sheybanish@mums.ac.ir+98 51 3840 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026