Evaluation of the hemodynamics changes in patients undergoing craniotomy surgery.

A clinical trial to comparison the effectiveness of labetalol and sufentanil with sufentanil on hemodynamic changes during intubation and scalp pin insertion in patients undergoing craniotomy surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130428013159N10

Enrollment

Registered

2020-02-20

Start date

2020-01-21

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic changes during intubation and scalp pin insertion. Unspecified adverse effect of drug or medicament

Interventions

Intervention 1: Intervention group: The intervention group I will receive 0.025 mg/kg diluted labetalol in 10 ml normal saline 5 minutes and 1 µ/kg sufentanil 3 minutes before tracheal intubation, als

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients undergoing craniotomy surgery ASA 1 and ASA 2 patients Aged between 18-65 years

Exclusion criteria

Exclusion criteria: History of cardiac diseases Hypertension History of drug alergy Ischemic heart disease COPD Sever respiratory disease(bronchial asthma) Conductive heart disease Hepatic disease Renal disease Obese patientswith BMI>30 Emergent surgeris

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: Before, 5, 10, 15, 30, and 60 minutes after skulp pin insertion. Method of measurement: Monitoring.;Mean blood pressure. Timepoint: Before, 5, 10, 15, 30, and 60 minutes after skulp pin insertion. Method of measurement: Monitoring.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShima Sheybani

Mashhad University of Medical Sciences

Sheybanish@mums.ac.ir+98 51 3840 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026