multiple sclerosis.
Conditions
Interventions
Intervention 1: Intervention: transcranial magnetic stimulation. Duration: 10 sessions( 5 sessions in one week and other 5 sessions in next week). Intervention 2: Control: no treatment.
Rehabilitation
Intervention: transcranial magnetic stimulation. Duration: 10 sessions( 5 sessions in one week and other 5 sessions in next week).
Sponsors
Kerman medical university-dean of research
Eligibility
Sex/Gender
All
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: All patients (20 to 40 years old ) met the Mc Donald criteria for diagnosis of MS.All of them belong to relapsing remitting MS subgroup. The study exclusion criteria included patients with EDSS > 3.5; new clinical attack during 3 months prior to the study; other neurological diseases (stroke, seizure, etc.); head trauma, chronic psychiatric disorder. Patients were right-handed based on the Edinburgh Handedness Inventory. Fatigue score based on Fatigue Severity Scale questionnaire should be less than 37. Depression score based on Beck Depression questionnaire should be less than 21. Mini mental state examination score should be more than 24.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mental rotation ability. Timepoint: befor rTMS implementation and after the 10th rTMS session. Method of measurement: Reaction time and accuracy (percent of correct response) were recorded.;Upper limb imagery chronometry. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: (real performance-motor imagery)/real performance.;Upper limb function. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: number of moved blocks in 1 minute.;Upper limb function. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: recorded time for moving nine pegs.;Lower limbs function. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: recorded time for walking 25 foots. | — |
Secondary
| Measure | Time frame |
|---|---|
| PASAT score. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: total number of accurate sum.;Motor and visual imagery vividness. Timepoint: before rTMS implementation. Method of measurement: kinesthetic and visual imagery questionnaire.;Global cognitive function. Timepoint: before rTMS implementation. Method of measurement: mini mental state examination.;Depression score. Timepoint: before rTMS implementation. Method of measurement: beck depression questionnaire.;Fatigue score. Timepoint: before rTMS implementation. Method of measurement: fatigue Severity scale questionnaire.;SDMT score. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: number of correct digits in 90 second.;Brief visuospatial memory test-revised score. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: number of correct responses after 25 minutes.;Judgment of line orientation score. Timepoint: before rTMS implementation and after the 10th rTMS session. Method of measurement: number of correct angles. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasser Zangiabadi
Kerman Neuroscience Research Center
Outcome results
None listed