Comparison of Metoclopramide and Ondansetrone with Prophylactic Phenylephrine Infusion Effects on Management of Nausea and Vomiting Associated with Spinal Anesthesia for Cesarean Section

Effect of combined Metoclopriomide-Phenylephrine-Ondansetron on nausea-vomiting during cesarean section

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013042210765N2

Enrollment

110

Registered

2014-01-14

Start date

2013-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nausea and Vomiting. other cpmplications of spinal and epidural anesthesia during labour and delivery

Interventions

Intervention 1: In patients of group 1,Phenylephrine infusion will start just before spinal anesthesia and the rate of infusion titrated that systolic BP remain =90 mmHg or in the range of20%from ba

Prevention

In patients of group 1,Phenylephrine infusion will start just before spinal anesthesia and the rate of infusion titrated that systolic BP remain =90 mmHg or in the range of20%from baseline .(500 µg

In patients of group 2 , phenylephrine infusion will start just before spinal anesthesia and the rate of infusion titrated that systolic BP remain =90 mmHg or in the range of 20% from baseline.(500

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria:Pregnant women with 34 or higher weeks of gestational age; candidate for elective Caesarean section and ASA physical status I and II. All Patients will give written informed consent. Exclusion criteria: Parturients with ASA physical status III or higher; Gastrointestinal diseases ;Anti emetic therapy in previous 24 hours;Patients who are sensitive to Ondansetron andMetoclopromide;Any treatment with MAO Inhibitors and three- cyclic antidepressants and patients with any contraindications of spinal anesthesia.

Exclusion criteria

Exclusion criteria:

Design outcomes

Secondary

Measure	Time frame
Blood pressure. Timepoint: The baseline of BP, after spinal anesthesia every 2 minute until 15 min, then every 5 min until the end of operation. Method of measurement: Noninvasive by new tech monitoring set.	—

Primary

Measure	Time frame
Nausea and Vomiting. Timepoint: After spinal anesthesia until 6 h. Method of measurement: The intencity of nausea and vomiting with Belville score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSousan Rasooli

Women's Reproductive Health Research Center, Tabriz University of Medical Sciences

Rasooli__s@yahoo.com+98 41 1553 9161

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026