psoriasis. Psoriasis vulgaris
Conditions
Interventions
Intervention 1: Herbal microemulsion: patients were instructed to apply the Herbal microemulsion of 0.5% curcumin twice a day on plaque lesions. Intervention 2: Placebo: patients were instructed to ap
Treatment - Drugs
Placebo
Herbal microemulsion: patients were instructed to apply the Herbal microemulsion of 0.5% curcumin twice a day on plaque lesions.
Placebo: patients were instructed to apply the Placebo microemulsion twice daily on plaque lesions.
Sponsors
Self supported and Islamic azad university pharmaceutical branch
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: patients diagnosed with plaque Psoriasis. both sexes (male and female) with the age group of 18-70 years old; stable patients with discontinued topical treatment for 2 weeks or 2 month for systemic treatments prior to the study. Exclusion criteria: pregnancy; lactation; patients with severe skin infections or any malignancies; history of allergies to the active ingredient of the product.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Redness. Timepoint: Week 0 (baseline), week 3,6,9 to complete the follow-up. Method of measurement: 1.Psoriasis questionnaire2.Psoriasis quality of life questionnaire3. photography: before, during &after treatment4. PASI calculator.;Thickness. Timepoint: Week 0 (baseline), week 3,6,9 to complete the follow-up. Method of measurement: 1.Psoriasis questionnaire2.Psoriasis quality of life questionnaire3. photography: before, during &after treatment4. PASI calculator.;Scaling. Timepoint: Week 0 (baseline), week 3,6,9 to complete the follow-up. Method of measurement: 1.Psoriasis questionnaire2.Psoriasis quality of life questionnaire3. photography: before, during &after treatment4. PASI calculator.;Involved area. Timepoint: Week 0 (baseline), week 3,6,9 to complete the follow-up. Method of measurement: 1.Psoriasis questionnaire2.Psoriasis quality of life questionnaire3. photography: before, during &after treatment4. PASI calculator.;PASI score. Timepoint: Week 0 (baseline), week 3,6,9 to complete the follow-up. Method of measurement: 1.Psoriasis questionnaire2.Psoriasis quality of life questionnaire3. photography: before, during &after treatment4. PASI calculator. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reported side effects (systemic and local). Timepoint: Patients were given a telephone number to call during treatment. Patient could report any side effects 24/7 as well as during follow-ups, all the way through the treatment and after completion. Method of measurement: Vigorous medical examination by the consultant dermatology in week 0,3,6,9 . Side effects Questionnaire, photography. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed