Effects of ? Crocin on depression

Effects of ? Crocin on major depressive disorder

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013041813058N1

Enrollment

Registered

2013-08-29

Start date

2013-05-08

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder (MDD). Major Depressive Disorder (MDD)

Interventions

Intervention 1: Intervention group: receive 20 mg Fluoxetine or SSRI (and if needed benzodiazepine as sedative) plus 2 tablet of Crocin(15 mg) for 4 weeks. Intervention 2: Control group: receive 20 mg

Treatment - Drugs

Intervention group: receive 20 mg Fluoxetine or SSRI (and if needed benzodiazepine as sedative) plus 2 tablet of Crocin(15 mg) for 4 weeks.

Control group: receive 20 mg Fluoxetine or SSRI (and if needed benzodiazepine as sedative) plus 2 tablet of Placebo for 4 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria : Diagnose and characterize of major depressive disorder base on the psychiatrist diagnose or structured clinical interview for DSM IV; Patients were selected in the range of 18 to 50 years old; patient satisfaction for play a part in this study based on confirming the related form; patients who have no psychotic symptoms; no substance abuse; patient with no risk of suicide thoughts. Exclusion criteria: having no criteria of MDD; patient aren't in age from 18 to 50 years; dissatisfaction of people to be in this study; having psychotic symptoms; substance abuse; patient with a significant risk of suicide.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Depressive Disorder. Timepoint: Before intervention, after one month intervention. Method of measurement: Beck depression and anxiety questionnaire, general health questionnaire (GHQ), the mood disorder questionnaire (MDQ) and demographic questionnaire.	—

Secondary

Measure	Time frame
Side effect of Crocin. Timepoint: Before intervention, after one month intervention. Method of measurement: Side effect evaluation questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyed Ahmad Mohajeri

Mashhad University of Medical Sciences

mohajeria@mums.ac.ir+98 51 1711 2618

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026