Effect of Crocin on Neoadjuvant Chemoradiotherapy in Patients with Esophageal Cancer

Sensitization Effects of Crocin to Radiation in Neoadjuvant Chemoradiotherapy in Patients with Esophageal Cancer

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130418013058N7

Enrollment

Registered

2018-03-09

Start date

2018-02-20

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophagus Cancer. Malignant neoplasm of esophagus, unspecified

Interventions

Intervention 1: Control group: Receiving two tablets of Placebo for four weeks along with chemotherapy drugs. Intervention 2: Intervention group: Receiving two tablets of Crocin (15 mg) for four wee

Eligibility

Sex/Gender

All

Age

No minimum to 80 Years

Inclusion criteria

Inclusion criteria: Middle and Lower Thoracic Esophagus Infected to Unifocal Esophageal Cancer Patient Candidate for Neoadjuvant Chemoradiotherapy Non-Metastatic Cancer

Exclusion criteria

Exclusion criteria: Dissatisfaction to Enter the Study Age Over 80 Years Taking Warfarin History of Using Psychiatric Drugs (Anti anxiety and Anti depressant)

Design outcomes

Primary

Measure	Time frame
Pathological Response After Surgery. Timepoint: One Month after Surgery. Method of measurement: Radiosensitizer.	—

Secondary

Measure	Time frame
Side Effects of Crocin. Timepoint: Before intervention, and one month later. Method of measurement: Questionnaire for Side Effect of Crocin.;Depression and Anxiety Disorder. Timepoint: Before intervention, and one month later. Method of measurement: Beck Depression and Anxiety Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyed Ahmad Mohajeri

Mashhad University of Medical Sciences

mohajeria@mums.ac.ir+98 51 3882 3251

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026