Effect of Crocin and Fluoxetine in Patients of Obsessive-Compulsive Disorder

Comparison of the effect of Crocin and Fluoxetine on Patients with Obsessive-Compulsive Disorder, in two treatment groups (Fluoxetine and Crorin); A Randomized Double Blind Clinical Trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130418013058N10

Enrollment

Registered

2018-12-04

Start date

2018-09-01

Completion date

Unknown

Last updated

2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-Compulsive Disorder. Obsessive-compulsive disorder, unspecified

Interventions

Intervention 1: Intervention group: Receiving One Capsule of Crocin (15 mg) for twelve weeks. Intervention 2: Intervention group: Receiving One Capsule of fluoxetine (20 mg) for twelve weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with Obsessive-Compulsive Disorder according to Diagnostic and Statistical Manual of Mental Disorders Scale 12 to 21 score of Yale-Brown Scale Do not receive any Psychiatric Medication 6 weeks Before the Start of the Study Written Consent for Participation No Some Disease such as; Heart, kidney, Liver disease and Blood disease

Exclusion criteria

Exclusion criteria: Other psychiatric disorders such as Behavioral Disorder and Bipolar disorder Consumption of Drug abuse Consumption of drugs that Effect on Obsessive-Compulsive Disorder such ac Lithium, Gabapentin and Buspiron Restrictive living conditions that Cause the Patient to not Complete the Course of Treatment and Needs Another Drug Sensitivity to saffron Pregnancy and lactation Alcohol addiction

Design outcomes

Primary

Measure	Time frame
Depression Disorder. Timepoint: Before Intervention, one, two and three months after the start of the study. Method of measurement: Beck Depression Questionnaire.;Anxiety Disorder. Timepoint: Before Intervention, one, two and three months after the start of the study. Method of measurement: Beck Anxiety Questionnaire.;Investigating Reduced Symptoms of Obsessive-Compulsive Disorder. Timepoint: Before Intervention, one, two and three months after the start of the study. Method of measurement: Measure a questionnaire of Yale- Brown scale and Hamilton Rating Scale tests.	—

Measure

Time frame

Depression Disorder. Timepoint: Before Intervention, one, two and three months after the start of the study. Method of measurement: Beck Depression Questionnaire.;Anxiety Disorder. Timepoint: Before Intervention, one, two and three months after the start of the study. Method of measurement: Beck Anxiety Questionnaire.;Investigating Reduced Symptoms of Obsessive-Compulsive Disorder. Timepoint: Before Intervention, one, two and three months after the start of the study. Method of measurement: Measure a questionnaire of Yale- Brown scale and Hamilton Rating Scale tests.

—

Secondary

Measure	Time frame
Side Effects of Crocin. Timepoint: During and after the study. Method of measurement: Questionnaire for Side Effect of Crocin.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Seyed Ahmad Mohajeri

Mashhad University of Medical Sciences

mohajeria@mums.ac.ir+98 51 3882 3251

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026