Preoperative consumption of N-Acetyl Cysteine and melatonin during CABGS

Evaluation of preoperative oral consumption of N-acetyl cysteine and melatonin as antioxidants in reducing the injuries caused by oxidative stress during Coronary Bypass Grafting Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201304178129N3

Enrollment

100

Registered

2013-06-17

Start date

2013-01-10

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases of the circulatory system. Ischaemic heart diseases

Interventions

Intervention 1: The second group:Melatonin( Tablets of 5 mg, oral,two times/day for 24 hours, the last dose, at one hour before the operation. Intervention 2: The placebo( dextrose, %5, dissolved in w

Prevention

Placebo

The second group:Melatonin( Tablets of 5 mg, oral,two times/day for 24 hours, the last dose, at one hour before the operation.

The placebo( dextrose, %5, dissolved in water,three times /day, for 48 hours.The last dose at one hour before the operation.

The first group: N-Acetyl cysteine(Effervescent tablets of 600 mg, three times/day for 48 hours, and the last dose, one hour before the operation.

Eligibility

Sex/Gender

All

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: The inclusion criteria: 1-Not having weak left ventricular function. 2- Non diabetics. 3- Non emergency patients. 4- patients without history of endocrine, pulmonary, metabolic and neurological diseases. Exclusion criteria: 1- Emergency patients. 2-Diabetic patients. 3- patients having history of endocrine, pulmonary, metabolic and neurological diseases. 4- smokers. 5-patients having weak left ventricular function. 6-Patients consuming melatonin and N-Acetyl cysteine at least from two weeks before the operation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Troponin T. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;Lactate. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;TNF- Alfa. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;Ck-MB. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;Added at 2016-10-27: Malondialdehyde. Timepoint: Added at 2016-10-27: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: Added at 2016-10-27: By spectrophtometry.	—

Measure

Time frame

Troponin T. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;Lactate. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;TNF- Alfa. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;Ck-MB. Timepoint: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: By ELISA method and commercial kits.;Added at 2016-10-27: Malondialdehyde. Timepoint: Added at 2016-10-27: Before the induction of anesthesia, after induction,during clamp, onset of reperfusion, 5 and 15 minutes on reperfusion and in Icu. Method of measurement: Added at 2016-10-27: By spectrophtometry.

—

Secondary

Measure	Time frame
BMI. Timepoint: Before the trial. Method of measurement: weight in kilograms divided by the square of height in meters.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Movahed

Bushehr University of Medical Sciences

a.movahed@bpums.iramovahed58@gmail.com+98 77 1252 9070

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026