The effect of donepezil on the persistent cognitive executive function deficit in traumatic brain injury patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130416013027N4

Enrollment

Registered

2020-08-17

Start date

2020-08-06

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

persistent cognitive executive function deficit in traumatic brain injury patients. Intracranial injury

Interventions

Intervention group: It consists of 17 people who, after performing baseline examinations and recording their results, are prescribed ?Donepezil 5 mg daily for the first week, 10 mg daily for the next

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with all severities of TBI Patients aged 18 to 60 years Patients with GOS 4 and 5 Consciousness level of10 to 15 At leaast 4 years of formal education MMSE score between 17-23 At least 3 months after discharge from hospital due to TBI

Exclusion criteria

Exclusion criteria: History of neurological diseases History of mental disorder and use of antipsychotic and antidepressant drugs, drug abuse while studying or last few months Cognitive and verbal disorders before TBI and sensory deprivations such as deafness and blindness, clinical instability or behavioral problems that prevent the subject from participating in the intervention Patient dissatisfaction with continuing to participate in the study

Design outcomes

Primary

Measure	Time frame
Cognitive executive function deficit. Timepoint: Before starting study and one month after starting study. Method of measurement: Before the intervention, the patients' cognitive level is determined by the physician using the Persian version of MMSE. The Digital Signal-Stop Executive Function Test Form is used to assess inhibitory control and executive function and information processing speed . In this test, the response time and accuracy of the response are measured. Digital tests to measure cognitive dimensions and information processing speed and performance, such as the Tower of London test (TLT), Cambridge gambling test (CGT), continuing performance test (CPT), lawton daily life activity test (IADL) are performed at the beginning and the end of the last treatment session.	—

Measure

Time frame

Cognitive executive function deficit. Timepoint: Before starting study and one month after starting study. Method of measurement: Before the intervention, the patients' cognitive level is determined by the physician using the Persian version of MMSE. The Digital Signal-Stop Executive Function Test Form is used to assess inhibitory control and executive function and information processing speed . In this test, the response time and accuracy of the response are measured. Digital tests to measure cognitive dimensions and information processing speed and performance, such as the Tower of London test (TLT), Cambridge gambling test (CGT), continuing performance test (CPT), lawton daily life activity test (IADL) are performed at the beginning and the end of the last treatment session.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZohair Reihanian

Rasht University of Medical Sciences

zoheir.reihanian@gmail.com+98 13 3336 8773

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026