The effect of ultra-low dose of naloxone on analgesia after abdominal wall nerves block in patients after cesarean section

The opioid sparing effect of adding ultra-low doses of naloxone to bupivacaine% 0/25 with or without sufentanil in Transverse Abdominis Plane Block on patients after elective caesarean section ;double- blind, randomized , clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013041212958N2

Enrollment

164

Registered

2013-06-07

Start date

2012-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pain. acute pain

Interventions

Intervention 1: under guidence of ultrasonography Transverse abdominis Block performed bilateraly in control group "patients recieved 18 ml bupivacaine 0.25% along with 2 cc normal saline on each s

Treatment - Drugs

under guidence of ultrasonography Transverse abdominis Block performed bilateraly in control group "patients recieved 18 ml bupivacaine 0.25% along with 2 cc normal saline on each sideIn the recove

under guidence of ultrasonography Transverse abdominis Block performed bilateraly in sufentanil group patients recieved 18 ml bupivacaine 0.25% along with 1 cc normal saline and 1 ml sufentanil (5 mic

under guidence of ultrasonography Transverse abdominis Block performed bilateraly in naloxone and sufentanil group patients recieved 18 ml bupivacaine 0.25% along with 1 cc naloxone (100 nanogram) al

under guidence of ultrasonography Transverse abdominis Block performed bilateraly in Naloxone group patients recieved 18 ml bupivacaine 0.25% along with 1 cc normal saline alon with 100 nanogram (1 m

Eligibility

Sex/Gender

Female

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: inclusion criteria: age 20-40; ASA class I,II; primigravid; non addict; without history of allergy to protocol drugs Excluxion criteria: patients whom recieved drugs other than the ones mentioned in protocol in 24 h preoperation; surgery duration more than 90 minutes

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain intesity. Timepoint: recovery room,2,6,12,24 h after surgery. Method of measurement: visual analoge scale.;Morphine consumption. Timepoint: recovery room, 2,6,12,24h after surgery. Method of measurement: opioid registration by milligram.	—

Secondary

Measure	Time frame
Sensory Block Duration. Timepoint: 24h. Method of measurement: Pinprick test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamira Sorbi

Tehran University of Medical Sciences

khatere80@yahoo.com+98 21 8490 2373

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026