Therapeutic abortion. Therapeutic Abortion
Conditions
Interventions
Intervention 1: In group A, patients received 400 mg of sub-lingual misoprestol every 6 hours to induce abortion and administration was discontinued in cases of severe contraction. Intervention 2: G
Treatment - Drugs
In group A, patients received 400 mg of sub-lingual misoprestol every 6 hours to induce abortion and administration was discontinued in cases of severe contraction.
Group B, received 400 mg of vaginal tablet of misoprestol, placing in the vagina every 6 hours and treatment carried on until delivery of fetus or induction of severe contractures.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria : All pregnant women with gestational age between 12 and 20 weeks who have medical indications for pregnancy termination 20-40 years old including fetal indications like structural or chromosomal fetal abnormalities, PROM, intrauterine fetal death or maternal indication such as pregnant women with hemoglobin less than 10 mg. Exclusion Criteria: pregnant women with any type of allergic reaction to misoprestol, pregnant women high risk for rupture of uterine, history of classic uterine incision or T-shaped incision, women with a history of extensive surgery on the fundus of the uterus, pregnant women with IUD, women with certain medical conditions such as severe anemia, clotting disorders or taking anticoagulant medication, active liver disease, glaucoma, uncontrolled seizure disorders, adrenal disease or disorder that requires treatment with glucocorticoids such as tracheobronchial asthma, Smoking more than 20 cigarettes per day, gynecologic abnormalities confirmed by ultrasound, mitral stenosis, sickle cell anemia, diastolic blood pressure more than 90 mm Hg, systolic pressure less than 90 mmHg, history of thromboembolism and liver disease, hemolytic disorders and a history of two cesareans.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete evacuation of products of conception. Timepoint: 24-48 h. Method of measurement: Questinaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulse rate. Timepoint: 24 and 48 hr. Method of measurement: examination.;Blood pressure. Timepoint: 24 and 48 hr. Method of measurement: examination.;Uterine contraction. Timepoint: 24 and 48 hr. Method of measurement: examination.;Mean induction to delivery time. Timepoint: 24 and 48 hr. Method of measurement: Questionaire.;Occurrence of side effects. Timepoint: 24 and 48 hr. Method of measurement: Questionaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNazila Mesbah
Tehran University of Medical Sciences
Outcome results
None listed