Treatment of osteoporosis in patients with spinal cord injury

Effect of 24 weeks advanced weight-bearing exercises with/without quadriceps and soleus functional electrical stimulation on femoral and tibial bone density indexes and functional activities in paraplegic spinal cord injury

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201304084952N3

Enrollment

Registered

2016-11-22

Start date

2016-10-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Thoracic spinal cord injury. Condition 2: Lumbar spinal cord injury. Condition 3: Osteoporosis. Other and unspecified injuries of thoracic spinal cord Other injury of lumbar spinal cord Osteoporosis without pathological fracture

Interventions

Intervention 1: First group: Patients who are undergo advanced weight bearing exercises (quadruped, trunk twisting and raising, tall-kneeling). Intervention 2: Third group: Control group, No intervent

Treatment - Other

First group: Patients who are undergo advanced weight bearing exercises (quadruped, trunk twisting and raising, tall-kneeling).

Third group: Control group, No intervention

Second group: Patients who will do trunk twisting and raising exercise alone and do quadruped and tall-kneeling with quadriceps and soleus functional electrical stimulation.

Eligibility

Sex/Gender

All

Age

20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Inclusion major criteria: Traumatic paraplegic spinal cord injury (T6 up T12 ,grade A or B); Since the lesion is at least 1 year; Age between 20 and 40 years; Ability to respond to electrical stimulation of the quadriceps and soleus muscles; Normal rang of motion in the hip, knee and ankle joints; medically stable; No previous fracture in areas that are scanned; No history of metabolic diseases and other disorders affecting calcium metabolism and density of bone, early menopause, cancer, arthritis, diabetes; No use the certain drugs affecting bone metabolism including steroids, estrogens, bisphosphonates and calcitonin, fluorides, thyroid hormones, lithium, anticonvulsants and anti-androgen; No routine and regular physiotherapy including weight bearing exercise program and electrotherapy during past 6 months. Exclusion major criteria: Lack of patient's cooperation; Creation of some problems such as fractures, infections.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Total bone mineral density. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Total cross section area. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Trabecular bone mineral density. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Cortical cross section area. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Cortical bone mineral density. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Cortical thickness. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Number of practice of trunk twisting and raising exercise. Timepoint: Before and after 24 weeks intervention. Method of measurement: Count.;Time exposure of quadruped position. Timepoint: Before and after 24 weeks intervention. Method of measurement: Digital timer.;Time exposure of tall-knelling position. Timepoint: Before and after 24 weeks intervention. Method of measurement: Digital timer.;Time exposure of forward reaching position. Timepoint: Before and after 24 weeks intervention. Method of measurement: Digital timer.	—

Measure

Time frame

Total bone mineral density. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Total cross section area. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Trabecular bone mineral density. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Cortical cross section area. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Cortical bone mineral density. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Cortical thickness. Timepoint: Before and after 24 weeks intervention. Method of measurement: quantitative compute tomography.;Number of practice of trunk twisting and raising exercise. Timepoint: Before and after 24 weeks intervention. Method of measurement: Count.;Time exposure of quadruped position. Timepoint: Before and after 24 weeks intervention. Method of measurement: Digital timer.;Time exposure of tall-knelling position. Timepoint: Before and after 24 weeks intervention. Method of measurement: Digital timer.;Time exposure of forward reaching position. Timepoint: Before and after 24 weeks intervention. Method of measurement: Digital timer.

—

Secondary

Measure	Time frame
Patient’s general health survey. Timepoint: Before and after 24 weeks intervention. Method of measurement: Persian version of the SF-36 questionnaire.;Level of independence in daily activities. Timepoint: Before and after 24 weeks intervention. Method of measurement: Persian version of the Barthel index.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMostafa Rahimi

Tarbiat Modares university

mostafa.rahimi@modares.ac.ir+98 21 7787 3060

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026