Evaluation of the effect of Metformin on thyroid function

Evaluation of the effects of Metformin on thyroid function in patients with sub-clinical Hypothyroidism

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT201304073565N8

Enrollment

Registered

2015-07-05

Start date

2015-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hypothyroidism. Subclinical iodine-deficiency hypothyroidism

Interventions

Intervention 1: In intervention group: Tablet Metformin 1gr each 12 hours for 3 months. Intervention 2: In control group: Placebo each 12 hours for 3 months.

Treatment - Drugs

In intervention group: Tablet Metformin 1gr each 12 hours for 3 months

In control group: Placebo each 12 hours for 3 months

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Having metabolic syndrome criteria; Thyrotropin levels between 5 to 10 miu / L Exclusion criteria: lack of consent; Renal insufficiency or GFR less than 50; Pregnancy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
TSH Level. Timepoint: Before and 3 months after study. Method of measurement: Elisa method.;T4 Level. Timepoint: Before and 3 months after study. Method of measurement: Elisa method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Zynolabedin Nurcheshmeh

Tabriz University of Medical Sciences

Nurcheshmehz@tbzmed.ac.ir+98 41 3337 3966

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026