Condition 1: Cholecystitis. Condition 2: post op use of opium. Condition 3: postoperative pain. Condition 4: post operative nausea and vomiting. Condition 5: surgical wound infection. Condition 6: calculus of gallbladder. Condition 7: calculus of ballblader without cholecystitis. Condition 8: calculus of gallbladder with other cholecystitis. Cholecyctitis unspecified Opioids and related analgesics abdominal and pelvic pain Nausea and vomiting Infection following a procedure, not elsewhere
Conditions
Interventions
Intervention 1: The intervention is one single dose of 2 grams of vitamin c of Osve pharmacological factory that made in IRAN ,that is equal to 4 vials of vitamin c that diluted with normal saline up
Treatment - Drugs
Placebo
The intervention is one single dose of 2 grams of vitamin c of Osve pharmacological factory that made in IRAN ,that is equal to 4 vials of vitamin c that diluted with normal saline up to 20 cc and in
In the control group 20 cc normal saline injected intravenously after general anesthesia before surgery
Sponsors
Faculty of medicine of Tehran University of Medical Siences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Patients who are considered for laparoscopic cholecystectomy (Laparoscopic surgery due to biliary Colic or cholecyctitis) Exclusion Criteria: Patients who are allergic to Narcotics or abusing drugs will be excluded from the study. In the case of necessity for simultaneous surgery, the patient will be excluded from the study. During 24- hour follow-up, Naloxone will be provided for the patients, and if patients’ respiratory rate drops below 12, PCA will be stopped and patient will be excluded from the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amount of opium used. Timepoint: 6 and 24 hours after surgery. Method of measurement: patient controlled anesthesia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea and vomiting. Timepoint: every 6 hours. Method of measurement: visual analoge scale.;Wound infection. Timepoint: after 7 days. Method of measurement: physical examination.;Patient satisfaction. Timepoint: after 24 hours. Method of measurement: sf 12 questionair.;Urinary retention. Timepoint: during 24 hours. Method of measurement: examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSara Emami
Dr Shariati Hospital, surgery ward
Outcome results
None listed