The effect of mannitol in reducing brain edema and increasing the level of consciousness in patients with brain injury

Effect of 0.5, 1, 1.5 g / kg doses of monnitol 20% in reduction of brain edema and increase in post-traumatic consciousness level in patients with diffuse axonal injury accompanied with edema and brain midline shifting more than 5 mm

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013040312888N1

Enrollment

Registered

2013-06-20

Start date

2010-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diffuse brain injury. Diffuse brain injury

Interventions

Intervention 1: mannitol 20% 0.5 mg/kg WB. Intervention 2: Mannitol%20 1g/kg WB. Intervention 3: mannitol%20 1.5g/kg WB.

Treatment - Drugs

mannitol 20% 0.5 mg/kg WB

Mannitol%20 1g/kg WB

mannitol%20 1.5g/kg WB

Eligibility

Sex/Gender

All

Age

15 Years to 60 Years

Inclusion criteria

Inclusion criteria: (Inclusion criteria: age 15 to 60 years, patients with diffuse axonal injury: level of consciousness of less than 8; edema and brian shifting from midline of more than 5 mm; willingness to participate in the study. Exclusion criteria: renal failure, intense electrolyte imbalance; death throughout the study)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Brain edema severity. Timepoint: On admission and 48 hours after admission. Method of measurement: Brain edema will be meseaured by CT scan on admission and 48 hours after admission and the findings will be graded based on the cistern basal being open, semi-open and close from1-3.	—

Secondary

Measure	Time frame
Brain midline shift. Timepoint: On admission and 48 hours after admission. Method of measurement: Brain edema will be meseaured by CT scan on admission and 48 hours after admission and will be calculated based on the midline shifting formula.(middle shift=biparietal diametr-2SP).;Level of consciousness. Timepoint: On admission and 48 hours after admission. Method of measurement: The GCS Glasgow Coma Scale score of 3 to 15 have been measured to be between.	—

Measure

Time frame

Brain midline shift. Timepoint: On admission and 48 hours after admission. Method of measurement: Brain edema will be meseaured by CT scan on admission and 48 hours after admission and will be calculated based on the midline shifting formula.(middle shift=biparietal diametr-2SP).;Level of consciousness. Timepoint: On admission and 48 hours after admission. Method of measurement: The GCS Glasgow Coma Scale score of 3 to 15 have been measured to be between.

—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026