The effect of Doxycycline on periodontal treatment in diabetics and non diabetics

Evaluating the effect of sub-antimicrobial dose Doxycycline as an adjuvant on periodontal treatments in diabetics and non diabetics

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013032212847N1

Enrollment

Registered

2013-05-29

Start date

2013-01-07

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate to Severe Chronic Periodontitis. Chronic Periodontitis, Diabetes Mellitus

Interventions

Intervention 1: Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for diabetic patients in interventional group 1, then oral Doxycycline 20 mg which was made by a drugstore

Treatment - Drugs

Treatment - Other

Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for diabetic patients in interventional group 1, then oral Doxycycline 20 mg which was made by a drugstore as much as need

Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for diabetic patients in interventional group 2.

Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for non diabetic patients in interventional group 3, then Doxycycline 20 mg which was made by a drugstore is prescribed bi

Scaling and root planning is done by an ultrasonic device (China, Woodpecker) for non diabetic patients in interventional group 4.

Eligibility

Sex/Gender

All

Age

30 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria include: Patients have at least 14 teeth, at least 8 pockets with PD (Probing Depth)=5 mm and CAL (Clinical Attachment Level)= 4 mm? do not be sensitive to Doxycycline family, do not use interfering drugs with Tetracycline (Anti Coagulants and Oral Contraceptives) and do not have antibiotic therapy or periodontal therapy in 4 months ago.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Probing depth. Timepoint: Before intervention and 3 months after intervention. Method of measurement: On millimeter scale and by William’s probe.;Clinical attachment level. Timepoint: Before intervention and 3 months after intervention. Method of measurement: On millimeter scale and by William’s probe.;Bleeding on probing. Timepoint: Before intervention and 3 months after intervention. Method of measurement: According to percentage of areas which have bleeding.	—

Measure

Time frame

Probing depth. Timepoint: Before intervention and 3 months after intervention. Method of measurement: On millimeter scale and by William’s probe.;Clinical attachment level. Timepoint: Before intervention and 3 months after intervention. Method of measurement: On millimeter scale and by William’s probe.;Bleeding on probing. Timepoint: Before intervention and 3 months after intervention. Method of measurement: According to percentage of areas which have bleeding.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactArezoo Khabazian

Shahid Sadoghi University of Medical Science-Yazd Dental School

arezookhabazian@yahoo.com+98 35 1621 2222

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026