Ketamin on reducing postoperative pain in cesarean section

The effect of subcutaneous ketamine infiltration on postoperative pain in elective cesarean section under spinal anesthesia.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT2013031710841N4

Enrollment

Registered

2013-04-22

Start date

2013-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cesarean postoperative pain. Complication of anaesthesia during the puerperium, unspecified

Interventions

Intervention 1: After closure perituine in K group 0.5mg/kg(0.05ml/kg) ketamin subcutaneously is infiltrated and patient is transferd to recovery room. Intervention 2: After closure perituine in P gro

Prevention

Treatment - Drugs

After closure perituine in K group 0.5mg/kg(0.05ml/kg) ketamin subcutaneously is infiltrated and patient is transferd to recovery room.

After closure perituine in P group (0.05ml/kg) normal salin subcutaneously is infiltrated and patient is transfered to recovery room.

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age between15-45 years old;ASA class 1&2; parturition candidate for cesarean section under spinal anesthesia. Exclusion criteria: history of hypertension; hyperthyroidism; convulsion; symptoms of increasing ICP ; psychiatric disorders; ischemic heart disease; valvular heart disease; allergy to Ketamin; liver & renal failure; alcohol or drugs abuse; spinal anesthesia contraindications(patients refuse, coagulation disorders, local infections, neurologic disorders, sever anemia,...) ; spinal failure & general anesthesia for surgery.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Diastolic Blood Pressure. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Pain score. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: 10 centimeter ruller.;Systolic Blood Pressure. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Heart rate. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Respiratory rate. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Observation & Examination.;Blood oxygenation. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Analgesic requirement in 24 hours. Timepoint: During 24 hours. Method of measurement: Observation & calculation.	—

Measure

Time frame

Diastolic Blood Pressure. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Pain score. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: 10 centimeter ruller.;Systolic Blood Pressure. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Heart rate. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Respiratory rate. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Observation & Examination.;Blood oxygenation. Timepoint: before drug adminstration; arrive to recovery; 30 minutes after stay in recovery;exit from recovery; 2, 4, 6, 8, 12 & 24 hours after sergury. Method of measurement: Non invasive Blood Pressure Monitoring.;Analgesic requirement in 24 hours. Timepoint: During 24 hours. Method of measurement: Observation & calculation.

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Secondary

Measure	Time frame
Nausea. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation.;Hallosination. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation &Examination.;Nistagmus. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation &Examination.;Sedation Level. Timepoint: pPreadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Ramsay Scale.;Vomiting. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation.	—

Measure

Time frame

Nausea. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation.;Hallosination. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation &Examination.;Nistagmus. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation &Examination.;Sedation Level. Timepoint: pPreadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Ramsay Scale.;Vomiting. Timepoint: Preadminstration, arrive to recovery, 30 minutes after stay in recovery,exit of recovery, 2- 4- 6- 8- 12 & 24 hours after sergury. Method of measurement: Observation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNahid Manouchehrian

Hamadan University of Medical Science

fatemieh@umsha.ac.ir+98 81 1827 7012

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026