mania. Other degenerative diseases of the nervous system
Conditions
Interventions
Intervention 1: Intervention group: Adding folic acid to therapeutic regime, in the form of 5 mg pill, once daily, for 4 months. Intervention 2: Control group: Adding placebo to the therapeutic regime
Placebo
Treatment - Drugs
Intervention group: Adding folic acid to therapeutic regime, in the form of 5 mg pill, once daily, for 4 months.
Control group: Adding placebo to the therapeutic regime ( sodium valproate), in the form of a pill, once daily, for 4 months.
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: having diagnosis of BD type 1,2 (DSM-IV-TR); age> 18 years. Exclusion criteria: mental retardation (IQ<70); pervasive developmental disorders; patients need ECT or physical controlling; contraindication to use of folic acid and folate dependent tumors; pregnancy; substance abuse or dependency since 3 months ago; risk of suicide which needs preventive interventions; weight lower than 30 kg; schizophrenia; medical or neurological disorders ( epilepsy and other seizure disorders); chronic gastrointestinal disorders; allergy to folic acid; renal disorders; use of supplements such as calcium, and D and B vitamins; chronic infection; anemia.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure and compare the response to treatment in study and control groups based on YMRS scale. Timepoint: After two weeks, one month, two months, three months. Method of measurement: by using Young Mania Rating Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Pashabadi
Member of Student Research Committee, Kermanshah University of Medical Sciences
Outcome results
None listed