unexplained chronic cough. Cough
Conditions
Interventions
Intervention 1: Intervention group or Intervene 1: Treatment will be done by cetirizine (letizen®) 10 milligram oral daily plus inhale budesonide Turbuhaler 200 microgram 2 puff every 12 hours for 25
Treatment - Drugs
Intervention group or Intervene 1: Treatment will be done by cetirizine (letizen®) 10 milligram oral daily plus inhale budesonide Turbuhaler 200 microgram 2 puff every 12 hours for 25 days.
Control group or Intervene 2: Treatment will be done by cetirizine (letizen®) 10 milligram oral daily plus Turbuhaler without effective drug (placebo) 2 puff every 12 hours for 25 days.
Sponsors
The budget will be funded by researchers.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: age over 18 years; unexplained chronic cough for more than 8 weeks; absence of underling cardiac diseases; do not using smoking and drugs; absence of clinical and para-clinical asthma evidence; normal chest x-ray; normal spirometry; absence of eosinophilic bronchitis (sputum eosinophil percentage less than 3%); negative (normal) inhaled methacholine provocation test; signed written consent; absence of pregnancy and breast feeding; did not taking steroids during the last 3 months; do not receive any treatment for chronic cough before and during study; do not taking Angiotensin converting enzyme inhibitors (ACEI). Exclusion criteria: dissatisfaction to continuing cooperation in each stage of the study; exacerbation or other accidents which requiring treatment; lack of returning within 48 hours of the deadline for second visit.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Budesonide inhalation treatment response in Numeric Cough Score questionnaire. Timepoint: Before intervention and a day after it. Method of measurement: Questionnaire.;Budesonide inhalation treatment response in visual analogue scale score. Timepoint: Before intervention and a day after it. Method of measurement: Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Budesonide inhalation treatment response with Forced Oscillation Technique spirometry parameters. Timepoint: Before intervention in two periods; before and after methacholine challenge test and a day after intervention. Method of measurement: Forced Oscillation Technique spirometry.;Budesonide inhalation treatment response with Fractional Exhaled Nitric Oxide. Timepoint: Before intervention and the day after it. Method of measurement: Fractional Exhaled Nitric Oxide test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi Yadollahzadeh
Tehran University of Medical Sciences
Outcome results
None listed