The effect of Biotin on muscle cramps in patients undergoing hemodialysis

The effect of Biotin on the severity and frequency of muscle cramps in patients undergoing hemodialysis

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130311012789N18

Enrollment

Registered

2018-04-28

Start date

2018-01-05

Completion date

Unknown

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Cramps. Cramp and spasm

Interventions

Intervention 1: Intervention group: In the intervention group, 1 mg of biotin was administered for 12 weeks. Intervention 2: Control group: The control group received placebo.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with chronic renal failure Muscle cramps at least once a week

Exclusion criteria

Exclusion criteria: Patient unwillingness to participate in the study Sensitivity to Biotin Necessity of taking vitamin C, vitamin E and carnitine

Design outcomes

Primary

Measure	Time frame
Severity , frequency and duration of muscle cramps. Timepoint: The first week and the twelfth week. Method of measurement: The severity of muscle cramps were measured using the visual analogue scale of pain and the number and duration of contractions were measured using seconds, minutes and hours.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Mohammadzadeh

Sanandaj University of Medical Sciences

sara66_med@yahoo.com+98 87 3366 4654

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026