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Comparing effect of intranasal Remifentanil with intranasal Dexmedetomidine on heart rate and blood pressure after tracheal intubation

Comparison effect of intranasal Remifentanil with intranasal Dexmedetomidine on changes in heart rate and blood pressure after laryngoscopy and tracheal intubation.

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130311012782N60
Enrollment
186
Registered
2024-03-15
Start date
2024-04-20
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation. Failed or difficult intubation

Interventions

Intervention 1: Intervention group 1: Receiving 1 µg/kg intranasal Dexmedetomidine 30 minutes before intubation. Intervention 2: Intervention group 2: Receiving 4 µg/kg intranasal Remifentanil 30 minu

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 18 to 65 years Requires general anesthesia (laryngoscopy and intubation). Agree to participate in the study Patients with ASA 1 and 2

Exclusion criteria

Exclusion criteria: Airway malformation Allergy to the studied drugs Prolongation of the laryngoscopy process for more than 15 seconds More than one attempt at intubation Dissatisfaction of patients and requests to withdraw from the study in any of the work steps.

Design outcomes

Primary

MeasureTime frame
Blood pressure. Timepoint: Before laryngoscopy and at 1, 3, 5 and 10 minutes after. Method of measurement: sphigmomanometer.;Heart bit. Timepoint: Before intubation and at 1, 3, 5 and 10 minutes after. Method of measurement: Pulse oximeter.;Blood oxygen saturation percentage. Timepoint: Before intubation and at 1, 3, 5 and 10 minutes after. Method of measurement: Pulse oximeter.

Secondary

MeasureTime frame
Laryngoscopy time. Timepoint: During tracheal intubation. Method of measurement: Calculation of the time interval from the beginning to the end of tracheal intubation.;Amount of drugs received for hemodynamic stability of the patient. Timepoint: From the start of tracheal intubation to the time of exit from recovery. Method of measurement: Through registration in the patient file.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe Lotfi

Esfahan University of Medical Sciences

lotfi.elahe1374@gmail.com+98 31 3669 2174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026