CAD. Atherosclerosis of coronary artery bypass graft(s), unspecified, with unstable angina pectoris
Conditions
Interventions
Intervention 1: In this group, 20 mg of oral Melatonin(made by Razak institute) is given to the patients 24 hours before the operation and 20 mg 2 hours before the operation. Intervention 2: In this g
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Age range above 40 years Candidate for coronary artery bypass surgery Not taking psychoactive drugs Absence of contraindications for the administration of melatonin and Q10 (pregnancy or decision to become pregnant, breastfeeding • Seizure disorders, bleeding disorders, autoimmune diseases such as rheumatoid arthritis, lupus, MS, High blood pressure, organ transplant, liver problems, kidney problems) Patient consent to participate in this study. No drug addiction
Exclusion criteria
Exclusion criteria: Need for another surgery Pump time higher than 120 minutes Reoperation required due to bleeding Death of the patient before completing the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of arrhythmia. Timepoint: ?During and after the pump, the first to third day of hospitalization in the intensive care unit. Method of measurement: by electrocardiography. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Urea Nitrogen(BUN). Timepoint: Before the operation and the first, second and third days of hospitalization in the intensive care unit. Method of measurement: Measurement of blood urea concentration by photometric method.;Blood creatinine level. Timepoint: Before the operation and the first, second and third days of hospitalization in the intensive care unit. Method of measurement: By Kinetic Jaffe method.;Blood pressure. Timepoint: Before the pump, during the pump, after the pump and the first to the third day of hospitalization in the intensive care unit. Method of measurement: By arterial catheter (arterial line).;Heart bit. Timepoint: Before the pump, after the pump and the first to the third day of hospitalization in the intensive care unit. Method of measurement: Pulse oximeter.;Restlessness and agitation. Timepoint: From the first to the third day of hospitalization in the intensive care unit. Method of measurement: By the Richmond scale.;Hospitalization time. Timepoint: From the time of admission to the discharge of the patient from the hospital. Method of measurement: By patient record.;Amount of Inotrope consumed. Timepoint: From the time of entering the operating room until the time of discharge from the intensive care unit. Method of measurement: Calculate the amount of inotrope consumed in milligrams.;Duration of mechanical ventilation. Timepoint: From the time of entering the operating room until the end of the endotracheal tube in the intensive care unit. Method of measurement: Calculation of the time interval from induction of anesthesia to removal of the endotracheal tube. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAmirreza Hemasian
Esfahan University of Medical Sciences
Outcome results
None listed