The effect of adding vitamin C tablets to the treatment regimen of patients with major depressive disorder

The effect of adding oral vitamin C to standard treatment of major depressive disorder

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130311012782N56

Enrollment

Registered

2021-07-12

Start date

2021-08-23

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder. Major depressive disorder, single episode

Interventions

Intervention 1: Intervention group: Daily administration of 500 mg of vitamin C tablets twice a day, in addition to routine treatment of major depressive disorder for two months. Intervention 2: Contr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Having major depressive disorder Patient consent to participate in the study Minimum literacy Has a high level of consciousness Has suitable conditions for completing the questionnaire

Exclusion criteria

Exclusion criteria: Drug addiction Underlying diseases such as diabetes, cardiovascular, lung, cancer Major changes in diet in recent months Verbal and auditory problems in which they are unable to communicate Antioxidant use one month before enrollment,

Design outcomes

Primary

Measure	Time frame
Intensity of Major Depressive Disorder. Timepoint: Before the intervention, one month and two months after the start of the intervention. Method of measurement: Using the Hamilton Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohamad Nadi Sakhvidi

Yazd University of Medical Sciences

nadi.sakhvidi@ssu.ac.ir+98 31 3669 2174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026