Comparison of injection of two different amounts of dexmedetomidine on blood pressure, heart rate and postoperative pain

Comparative study of the effect of two-dose infusion of 0.3 and 0.6 µg / kg dexmedetomidine during surgery on changes in hemodynamic parameters and pain in patients undergoing spinal surgery under general anesthesia

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130311012782N53

Enrollment

Registered

2021-03-15

Start date

2021-04-03

Completion date

Unknown

Last updated

2021-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disk herniation. Disk herniation

Interventions

Intervention 1: Intervention group1: Patients receiving intravenous infusion of 0.3 µg / kg dexmedetomidine at the time of induction of anesthesia. Intervention 2: Intervention group2: Patients receiv

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Candidate for spinal laminectomy under general anesthesia ASA(American Society of Anesthesiologists) 1 & 2 Patient consent to participate in the study

Exclusion criteria

Exclusion criteria: History of kidney and liver disease History of allergy to any anesthetic drug Heart failure or a history of miocardial infarction Drug and alcohol addiction or mental illness Pregnancy

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Every half hour during surgery and recovery. Method of measurement: Pulse Oximeter.;Hear rate. Timepoint: Every half hour during surgery and recovery. Method of measurement: Pulse Oximeter.;Percentage of blood oxygen saturation. Timepoint: Every half hour during surgery and recovery. Method of measurement: Pulse Oximeter.;Post operative pain. Timepoint: Every 30 minutes from the enterance to recovery and 2, 8, 24 and 48 hours after surgery. Method of measurement: Using a visual analog scale(VAS) that divides patients' pain intensity from zero to 10.	—

Measure

Time frame

Blood pressure. Timepoint: Every half hour during surgery and recovery. Method of measurement: Pulse Oximeter.;Hear rate. Timepoint: Every half hour during surgery and recovery. Method of measurement: Pulse Oximeter.;Percentage of blood oxygen saturation. Timepoint: Every half hour during surgery and recovery. Method of measurement: Pulse Oximeter.;Post operative pain. Timepoint: Every 30 minutes from the enterance to recovery and 2, 8, 24 and 48 hours after surgery. Method of measurement: Using a visual analog scale(VAS) that divides patients' pain intensity from zero to 10.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahshad Rahimian

Esfahan University of Medical Sciences

k.mahshad-net@yahoo.com+98 31 3669 2174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026