Comparison of the effect of retplasia and surgery in the treatment of infection around the pleura

Comparison of the effect of Video Assisted thoracoscopic surgery(VATS) with Reteplase fibrinolytic injection in the pleural space through chest tube in children with empyema

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20130311012782N51

Enrollment

Registered

2021-02-02

Start date

2021-04-08

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

empyema. Pyothorax without fistula

Interventions

Intervention 1: Intervention group 1: In this group, patients undergo thoracoscopic decoction surgery. Intervention 2: Intervention group 2: In this group, the fibrinolytic drug Retplase made by Osweh

Eligibility

Sex/Gender

All

Age

1 Years to 15 Years

Inclusion criteria

Inclusion criteria: known stage 2 empyema candidate for VATS surgery or fibrinolytic injection age range 15-1 years parental consent to participate in the study

Exclusion criteria

Exclusion criteria: previous lung and chest surgery Having a coagulation disorder prohibition of the use of fibrinolytic drugs

Design outcomes

Primary

Measure	Time frame
Changes in severity of Empyema. Timepoint: Two weeks after treatment. Method of measurement: clinical evaluation.;Length of hospitalization. Timepoint: End of the treatment. Method of measurement: Patient record.;Duration of hospitalization in the intensive care unit. Timepoint: Time to leave the intensive care unit. Method of measurement: Patient record.;Duration of receiving antibiotics. Timepoint: End of treatment. Method of measurement: Patient record.;Duration of the chest tube. Timepoint: End of treatment. Method of measurement: Patient record.	—

Measure

Time frame

Changes in severity of Empyema. Timepoint: Two weeks after treatment. Method of measurement: clinical evaluation.;Length of hospitalization. Timepoint: End of the treatment. Method of measurement: Patient record.;Duration of hospitalization in the intensive care unit. Timepoint: Time to leave the intensive care unit. Method of measurement: Patient record.;Duration of receiving antibiotics. Timepoint: End of treatment. Method of measurement: Patient record.;Duration of the chest tube. Timepoint: End of treatment. Method of measurement: Patient record.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Kaviani

Esfahan University of Medical Sciences

hkaveh57@gmail.com+98 31 3669 2174

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026