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omparison effect of single dose of Methotrexate and Actinomycin D in the prevention of gestational trophoblastic neoplasia in patients with high risk hydatidiform mole

Comparison effect of single dose of Methotrexate and Actinomycin D in the prevention of gestational trophoblastic neoplasia in patients with high risk hydatidiform mole who refer to Shahid Beheshti and Azahra hospitals of Isfahan university of medical sciences in 2020

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20130311012782N40
Enrollment
90
Registered
2020-02-25
Start date
2020-04-02
Completion date
Unknown
Last updated
2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gestational trophoblastic neoplasia. gestational trophoblastic neoplasm

Interventions

Intervention 1: Intervention group: Intravenous injection of a single dose of actinomycin D and then washing the vein with 10 ml distilled water one hour before suction curettage. Intervention 2: Inte

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
40 Years to No maximum

Inclusion criteria

Inclusion criteria: Full molar pregnancy mother age above 40 years old Patient's consent to participate in the study Patient Preparation for Surgery and Termination of Pregnancy with Suction for Molar Discharge Having risk factors for pregnancy progression to trophoblastic neoplasia

Exclusion criteria

Exclusion criteria: serum level of B-hCG >=100000 iu/ml theca lutein cyst size >=6 cm

Design outcomes

Primary

MeasureTime frame
Incidence of gestational trophoblastic neoplasia in Molar pregnancy. Timepoint: Every week for three weeks and the 6 months later. Method of measurement: measurement of beta HCH.—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamaneh Maghzi

Esfahan University of Medical Sciences

samaneh.maghzi@gmail.com+98 31 3669 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026